Summary
Ultrastructural and histochemical features of three muscle fiber changes — branched fibers, large fibers and necrotic fibers — have been studied in Bar Harbor strain 129 dystrophic mice. The pathogenesis of these changes, which are considered to be responses to injury, have been discussed. Although these changes are not regarded as specific, they are characteristic of the histopathology of muscular dystrophy, so that an understanding of the mechanisms which produce these abnormal muscle fibers should contribute to the knowledge of the dystrophic process.
Zusammenfassung
Die ultrastrukturellen und histochemischen Merkmale von drei Muskelfaserveränderungen — Faserverzweigung, große Fasern und nekrotische Fasern — wurden an 129 dystrophischen Bar Harbor-Mäusen untersucht. Die Pathogenese dieser Veränderungen, die als Schädigungsfolgen aufgefaßt werden, wird diskutiert. Obwohl diese Veränderungen nicht als spezifisch angesehen werden, sind sie doch charackteristisch für die Histopathologie der Muskeldystrophie, so daß das Verständnis des Mechanismus, der diese abnormen Muskelfasern hervorbringt, zur Kenntnis des dystrophischen Prozesses beitragen dürfte.
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This work was supported by a post doctoral fellowship from the Muscular Dystrophy Associations of America, Inc. (Dr. Bray), a Research Career Development Award from the National Institute of Neurological Diseases and Stroke (Dr. Banker) and research grants from the Muscular Dystrophy Associations of America and Canada.
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Bray, G.M., Banker, B.Q. An ultrastructural study of degeneration and necrosis of muscle in the dystrophic mouse. Acta Neuropathol 15, 34–44 (1970). https://doi.org/10.1007/BF00690687
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DOI: https://doi.org/10.1007/BF00690687