Summary
Permeability changes of vasa nervorum and exudation of serum albumin in a nutritional peripheral neuropathy induced by isonicotinic acid hydrazide (INH) in rats were studied by menas of fluorescence microscopic tracing of intravenously injected albumin tagged with Evans blue or with fluorescein isothiocyanate.
All rats given INH for fourteen days which developed histologically demonstrable neuropathy also showed abnormal vascular permeability and exudation of the albumin conjugate into the endoneurium. Once outside the blood vessels the conjugate had a predilection for spreading in the endoneurial interstices along the nerves.
Thus, like traumatic peripheral neuropathies, this nutritional neuropathy is associated with permeability changes of vasa nervorum and exudation of serum albumin in the endoneurium. The simultaneous occurrence of nerve fibre lesions and permeability changes of vasa nervorum indicates that these two phenomena are in some way related to each other.
Zusammenfassung
Bei einer durch perorale Applikation von Isonicotinsäurehydrazid (INH) induzierten peripheren Neuropathie der Ratte wurden die Permeabilitätsänderungen der Vasa nervorum und die Exsudation von Serumalbumin mittels fluorescenzoptischen Nachweises von i.v. injiziertem, an Evansblue oder Fluoresceinisothiocyanat gekoppelten Albumin untersucht.
Alle Ratten, denen 14 Tage hindurch INH verabreicht worden war und die eine histologisch nachweisbare Neuropathie entwickelten, zeigten abnorme Gefäßpermeabilität und Exsudation des Albuminkonjugates in das Endoneurium. Nach dem Austritt aus den Gefäßen zeigte das Konjugat vorzugsweise Ausbreitung im endoneuralen Interstitium.
Ähnlich wie traumatische Nervenschädigungen ist diese nutritive Neuropathie demnach mit Permeabilitätsänderungen der Vasa nervorum und Exsudation von Serumalbumin in das Endoneurium vergesellschaftet. Das gleichzeitige Auftreten von Nervenfaserläsionen und Permeabilitätsänderung der Vasa nervorum spricht dafür, daß beide Phänomene irgendwie miteinander in Beziehung stehen.
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Supported by grants from the Swedish Multiple Sclerosis Society and from the Swedish Medical Research Council, Project B 68-12X-82-04.
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Olsson, Y. Studies on vascular permeability in peripheral nerves. Acta Neuropathol 11, 103–112 (1968). https://doi.org/10.1007/BF00690214
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DOI: https://doi.org/10.1007/BF00690214