Summary
Dopamine (DA), serotonin (5-HT), and 5-hydroxyindole acetic acid (5-HIAA) were assayed spectrofluorometrically in various brain regions of 8 human patients who died after acute and old cerebral infarction. In both recent and older infarcts a total depletion of DA and 5-HT was associated with slight reduction of DA and 5-HT levels in remote nonischemic areas and various nuclei of both the injured and contralateral hemispheres. 5-HIAA was significantly reduced in acute ischemic necrosis, while the perifocal edema zone showed considerable accumulation of both 5-HT and 5-HIAA. The degradation zone surrounding old infarcts showed a mild decrease of both 5-HT and 5-HIAA, indicating normalization of 5-HT metabolism and turnover after decrease of cerebral edema. These preliminary data which confirm previous findings in experimental cerebral ischemia and infarct indicate that disorders of brain monoamine metabolism are contributing to the development of postischemic brain damage and the complicating cerebral edena.
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References
Anton, A. H., Sayre, D. F.: The distribution of dopamine and dopa in various animals and a method for their determination in diverse biological material. J. Pharm. exp. Ther.145, 326–336 (1964)
Asheroft, G. W., Sharman, F. D.: Drug induced changes in the concentration of 5-OR indolyl compounds in the cerebrospinal fluid and caudate nucleus. Brit. J. Pharmacol.19, 153–160 (1962)
Birkmayer, W., Danielczyk, W., Neumayer, E., Riederer, P.: Nucleus ruber andl-Dopa psychosis: biochemical and post-mortem findings. J. Neural. Transm.35, 95–116 (1974)
Jakoby, W. B., Scott, E. M.: Aldehyde oxidation. III. Succinic semialdehyde dehydrogenase. J. Biol. Chem.234, 936–940 (1959)
Jellinger, K., Riederer, P.: Brain monoamines in metabolic coma and stroke. In: Pathology of Cerebrospinal Microcirculation (eds. J. Cervós-Navarro, E. Betz and R. Wüllenweber). New York: Raven Press (in press)
Klatzo, I.: Pathophysiologic aspects of cerebral ischemia. In: The nervous system (ed. D. B. Tower), pp. 313–321. New York: Raven Press 1975
Kogure, K., Scheinberg, P., Kishikawa, H., Busto, H.: The role of monoamines and cyclic AMP in ischemic brain edema. In: Dynamics in brain edema (eds. H. M. Pappius, and W. Feindell), pp. 203–214. Berlin-Heidelberg-New York: Springer 1976.
Lavyne, M., Moskowitz, M. A., Larin F., Zervas, N., Wurtman, R. J.: Brain3H-catecholamine metabolism in experimental cerebral ischemia. Neurology (Minneap.)25, 483–485 (1975)
Lloyd, K. G., Farley, I. J., Deck, J. H. N., Hornykiewicz, O.: Serotonin and 5-hydroxyindoleacetic acid in discrete areas of the brainstem of suicide victims and control patients. Adv. Biochem. Psychopharm.11, 387–397 (1974)
McGeer, P. L., Grewaal, D. S., McGeer, E. G.: Effect on extrapyramidal GABA levels of drugs which influence dopamine and acetylcholine metabolism. In: Advances in Parkinsonism (eds. W. Birkmayer and O. Hornykiewicz), pp. 132–140. Basel: Hoffman-La Roche Editions 1976
Meyer, J. S., Okamoto, S., Shimaza, K.: Disordered neurotransmitter function demonstrated by measurement of norepinephrine and 5-hydroxytryptamine in CSF of patients with recent cerebral infarction. Brain97, 655–664 (1974)
Moskowitz, M. A., Wurtman, R. J.: Acute stroke and brain monoamines. In: Cerebrovascular diseases (ed. P. Scheinberg), pp. 153–166. New York: Raven Press 1976
Mrsulja, B. B., Mrsulia, B. J., Spatz, M., Ito, U., Walker, J. T. Jr., Klatzo, I.: Experimental cerebral ischemia in mongolian gerbils. IV. Behaviour of biogenic amines. Acta neuropath. (Berl.)36, 1–8 (1976)
Mrsulja, B. B., Lust, W. D., Mrsulja, B. J., Passenneau, J. V.: Effect of repeated cerebral ischemia on metabolites and metabolic rate in gerbil cortex. Brain Res.119 480–489 (1977)
Mrsulja, B. B., Mrsulja, B. J., Spatz, M., Klatzo, I.: Monoamines in cerebral ischemia in relation to brain edema. In: Dynamics of brain edema (eds. H. H. Pappius and W. Feindell), pp. 187–192. Berlin-Heidelberg-New York: Springer 1976
Riederer, P.: On the significance of GABA determination in human postmortem material. (in preparation)
Riederer, P., Wuketich, St.: Time course of nigrostriatal degeneration in Parkinson's disease. J. Neural. Transm.38, 277–301 (1976)
Rinne, U. K., Sonninen, V., Hyyppä, M.: Effect ofl-Dopa on brain monoamines and their metabolism in Parkinson's disease. Life Sci.10, 549–557 (1971)
Robinson, R., Shoemaker, W., Schlumpf, M., Valk, T., Bloom, F. E.: Effect of experimental cerebral infarction in rat brain on catecholamines and behaviour. Nature255, 332–334 (1975)
Welch, K. M. A., Chabi, E., Buckingham, J., Bergin, B., Achar, V. S., Meyer, J. S.: Catecholamine and 5-hydroxytryptamine levels in ischemic brain. Influence of p-chlorophenyl-alanine. Stroke8, 341–346 (1977)
Welch, K. M. A., Chabi, E., Dodson, R. F., Wang, T. P. F., Nell, J., Bergin, B.: The role of biogenic amines in the progression of cerebral ischemia and edema. In: Dynamics of brain edema (eds. H. H. Pappius and W. Feindell), pp. 193–202. Berlin-Heidelberg-New York: Springer 1976
Westergaard, E.: The blood-brain-barrier to horseradish peroxidase under normal and experimental conditions. Acta neuropath. (Berl.)39, 181–186 (1977)
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Jellinger, K., Riederer, P. & Kothbauer, P. Brain monoamines in human cerebral infarcts. Acta Neuropathol 41, 173–176 (1978). https://doi.org/10.1007/BF00689771
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DOI: https://doi.org/10.1007/BF00689771