Summary
A man aged 20 with sudden onset of headaches and rapidly evolving spastic quadriparesis died within 3 weeks. Pathologic examination revealed intensive inflammation confined mainly to the adventitia of the aorta, the internal carotids, and all the major intracranial arteries. The gross changes and the lymphocytic and plasma cell nature of the inflammatory infiltrates were typical of Takayasu's arteritis. Thrombosis of the right internal carotid artery resulted in ischemic necrosis of the ipsilateral hemisphere. Quite recent thrombus occluded the left internal carotid artery. This seems to be the first case report on histologically proven extensive direct involvement of intracranial vessels in Takayasu's disease. The differential diagnostic aspects of the case are also briefly discussed.
This is a preview of subscription content, log in via an institution to check access.
References
Akikusa B, Kondo Y, Muraki N (1981) Aortic insufficiency caused by Takayasu's arteritis without usual clinical features. Arch Pathol Lab Med 105:650–651
Ask-Upmark E (1954) On the pulseless disease outside of Japan. Acta Med Scand 149:161–178
Aufderheide AC, Henke BW, Parker EH (1981) Granulomatous coronary arteritis (Takayasu's disease). Arch Pathol Lab Med 105:647–649
Cohle SD, Titus JL, Espinola A, Jachimezyk JA (1982) Sudden unexpected death due to coronary giant cell arteritis. Arch Pathol Lab Med 106:171–172
Hall GH (1973) Giant cell arteritis — an unholy trinity. Am Heart J 85:835–837
Juzi U (1967) Takayasusche Arteritis mit Herzinfarkt. Schweiz Med Wochenschr 47:397–405
Lupi-Herrara E, Sanchez-Tones G, Marcushamer J, Mispireta J, Horwitz S, Vela JE (1977) Takayasu's arteritis. Clinical study of 107 cases. Am Heart J 93:94–103
Mullick FG, McAllister HA, Wagner BM, Feneglio JJ (1979) Drug related vasculitis. Clinicopathologic correlations in 30 patients. Human Pathol 10:313–325
Nakao FK, Ikeda M, Kimata S, Niitani H, Miyahara M, Ishimi Z, Hashiba K, Takeda Y, Ozawa T, Matsushita S, Kuramechi M (1967) Takayasu's arteritis. Clinical report of eighty-four cases and immunological studies of seven cases. Circulation 35:1141–1155
Nasu T (1963) Pathology of pulseless disease: A systematic study and critical review of 21 autopsy cases reported in Japan. Angiology 14:225–242
Riehl J-L, Brown WJ (1965) Takayasu's arteritis. An autoimmune disease. Arch Neurol 12:92–97
Rose AG, Sinclair-Smith CC (1980) Takayasu's arteritis. A study of 16 autopsy cases. Arch Pathol Lab Med 104:231–237
Rosen FN, Gaton E (1972) Takayasu's arteritis of coronary arteries. Arch Pathol 94:225–229
Schrire V, Asherson RA (1964) Arteritis of the aorta and its major branches. Q J Med 33:439–463
Yates PO (1976) Vascular disease of the central nervous system. In: Blackwood W, Corsellis JAN (eds) Greenfield's neuropathology. Year Book Medical Publishers, Chicago, pp 86–148
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Molnár, P., Hegedüs, K. Direct involvement of intracerebral arteries in Takayasu's arteritis. Acta Neuropathol 63, 83–86 (1984). https://doi.org/10.1007/BF00688476
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00688476