Summary
The midbrains of pups with congenital hydrocephalus spontaneously occurring in MT/HokIdr mice were histologically examined. The subcommissural organ (SCO) and the posterior commissure were completely absent in the hydrocephalic brain. The cerebral aqueduct in the hydrocephalic brain was never completely stenosed, though it was somewhat narrowed in its middle region as compared with that in the normal brain. a possible interrelationship between an absence of SCO and a cause of congenital hydrocephalus is discussed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Borit A (1976) communicating hydrocephalus causing aqueductal stenosis. Neuropadiatrie 7:416–422
Diederen JHB, Vullings HGB, Rombout JHWM, de Gunst-Schoonderwoerd ATM (1983) The subcommissural organiquor fibre complex: the binding of catecholamines to the liquor fibre in frogs of theRana esculenta complex. Acta Zool (Stockh)64:47–53
Ferres-Torres R, Castaneyra-Perdomo A, Ramos-Navarro J (1985) Quantitative development of the subcommissural organ in hypothyroid mice. Brain Res 331:348–352
Gilbert GJ (1960) The subcommissural organ. Neurology 10:138–142
Hess J, Sterba G (1973) Studies concerning the function of the complex subcommissural organ-liquor fibre: the binding ability of the liquor fibre to pyrocatechin derivatives and its functional aspects. Brain Res 58:303–312
McMillan JJ, Williams B (1977) Aqueduct stenosis. Case review and discussion. J Neurol Neurosurg Psychiatry 40:521–532
Newberne PM (1962) The subcommissural organ of the vitamin B12 deficient rat. J Nutr 76:393–414
Nugent GR, Al-Mefty O, Chou S (1979) Communicating hydrocephalus as a cause of aqueductal stenosis. J Neurosurg 51:812–818
Overholser MD, Whitley JR, O'Dell BL, Hogan AG (1954) The ventricular system in hydrocephalic rat brains produced by a deficiency of vitamin B12 and folic acid in the maternal diet. Anat Rec 120:917–934
Raimondi AJ, Clark SJ, McLone DG (1976) Pathogenesis of aqueductal occlusion in congenital murine hydrocephalus. J Neurosurg 45:66–77
Takeuchi IK, Takeuchi YK (1986) Congenital hydrocephalus following X-irradiation of pregnant rats on an early gestational day. Neurobehav Toxicol Teratol 8:143–150
Weindl A (1973) Neuroendocrine aspects of circumventricular organs. In: Ganong WF, Martini L (eds) Frontiers in neuroendocrinology. Oxford Univ Press, London, pp 3–32
Weindl A, Schinko I (1975) Evidence by scanning electron microscopy for ependymal secretion into the cerebrospinal fluid and formation of Reissner's fiber by the subcommissural organ. Brain Res 88:319–324
Williams B (1973) Is aqueduct stenosis a result of hydrocephalus? Brain 96:399–412
Woollam DHM, Collins P (1980) Reissner's fibre in the rat: a scanning and transmission electron microscope study. J Anat 131:135–143
Ziegels J (1976) The vertebrate subcommissural organ: a structural and functional review. Arch Biol 87:429–476
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Takeuchi, I.K., Kimura, R., Matsuda, M. et al. Absence of subcommissural organ in the cerebral aqueduct of congenital hydrocephalus spontaneously occurring in MT/HokIdr mice. Acta Neuropathol 73, 320–322 (1987). https://doi.org/10.1007/BF00688253
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00688253