Summary
The relation of lymphoma cells to gliomesenchymal stroma within nervous tissue was studied by peroxidase-antiperoxidase immunostaining of formalin-fixed and paraffin-embedded surgical specimens for fibronectin (FN), factor VIII-related antigen and glial fibrillary acidic protein in 17 malignant non-Hodgkin lymphomas of the brain. For comparison, 9 non-Hodgkin lymphomas, 6 Hodgkin lymphomas, and 19 plasmacytomas of the spinal or cranial epidural spaces were studied with the same methods. Lymphoma cells were consistently negative for all markers. All lymphomas of the brain showed conspicuous concentric perivascular circles of immunoreactivity for FN in parts infiltrating brain tissue. Such structures are considered to derive from splitting of basal laminae of preexisting brain vessels; they were not seen in tumors of the epidural space. Cells with conspicuous FN content were found in brain as well as in epidural lymphomas. A monohistiocytic origin of those cells was confirmed by presence of monohistiocytic markers lysozyme and α-1-antichymotrypsin. Thus, additional immunostaining for FN seems to be useful for detecting monohistiocytes/macrophages in brain tumors.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Allegranza A, Mariani C, Giardini C, Brambilla MC, Boeri R (1984) Primary malignant lymphomas of the central nervous system: a histological and immunological study of 12 cases. Histopathology 8:781–791
Cohen AS, Shirahama T, Sipe JD, Skinner M (1983) Amyloid proteins, precursors, mediator, and enhancer. Lab Invest 48:1–4
D'Ardenne AJ, Kirkpatrick P, Sykes BC (1984) Distribution of laminin, fibronectin, and interstitial collagen type III in soft tissue tumors. J Clin Pathol 37:895–904
DuBoulay CEH (1982) Demonstration of fibronectin in soft tissue tumors using immunoperoxidase technique. Diagn Histopathol 5:283–289
Giordana MT, Germano I, Giaccone G, Mauro A, Migheli A, Schiffer D (1985) The distribution of laminin in human brain tumors: an immunohistochemical study. Acta Neuropathol (Berl) 67:51–57
Herpers MJHM, Budka H, McCormick D (1984) Production of glial fibrillary acidic protein (GFAP) by neoplastic cells: adaptation to the microenvironment. Acta Neuropathol (Berl) 64:333–338
Hirano A, Ghatak NR, Becker NH, Zimmermann HM (1974) A comparison of the fine structure of small blood vessels in intracranial and retroperitoneal malignant lymphomas. Acta Neuropathol (Berl) 27:93–104
Houthoff HJ, Poppema S, Ebels EJ, Elema JD (1978) Intracranial malignant lymphomas. A morphologic and immunocytologic study of twenty cases. Acta Neuropathol (Berl) 44:203–210
Ishida Y (1975) Fine structure of primary reticulum cell sarcoma. Acta Neuropathol (Berl) [Suppl] VI:147–153
Jellinger K, Slowik F, Sluga E (1979) Primary intracranial malignant lymphomas. A fine structural, cytochemical and CSF immunological study. Clin Neurol Neurosurg 81:173–184
Kalimo H, Lehto M, Näntö-Salonen K, Jalkanen M, Risteli J, Narva EV (1985) Characterization of the perivascular reticulun network in a case of primary brain lymphoma. Acta Neuropathol (Berl) 66:299–305
Kochi N, Tani E, Morimura T, Itagaki T (1983) Immunohistochemical study of fibronectin in human glioma and meningioma. Acta Neuropathol (Berl) 59:119–126
Lennert K (1975) Morphology and classification of malignant lymphomas and so-called reticuloses. Acta Neuropathol (Berl) [Suppl] VI:1–16
Menzel EJ, Borth W, Kaik B (1983) Wechselwirkungen zwischen Fibronectin und aggregiertem IgG. Wien Klin Wochenschr 95:880–884
Möller P, Achtstätter H, Butzengeiger M, Schüle B (1983) The distribution of fibronectin in lymph nodes infiltrated by Hodgkin's disease. An immunoperoxidase study on paraffin sections. Virchows Arch [A] 400:319–329
Papadimitriou CS, Stephanski-Nikou SN, Malamou-Mitsi VD (1983) Comparative immunostaining of T-associated plasma cells and other lymph node cells in paraffin sections. Virchows Arch [Cell Pathol] 43:31–36
Reilly JT, Nash JR, Mackie MJ, McVerry BA (1985) Distribution of fibronectin and laminin in normal and pathological lymphoid tissue. J Clin Pathol 38:849–854
Taylor CR, Russel R, Lukes RJ, Davis RL (1978) An immunohistological study of immunoglobulin content of primary central nervous system lymphomas. Cancer 41:2197–2205
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kochi, N., Budka, H. & Radaszkiewicz, T. Development of stroma in malignant lymphomas of the brain compared with epidural lymphomas. Acta Neuropathol 71, 125–129 (1986). https://doi.org/10.1007/BF00687973
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00687973