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Orientated tubules in axoplasm of cerebellar myelinated nerve fibres in the rat

A study of normal and scrapie animals

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Summary

Arrays of longitudinally arranged tubular structures were found in the axoplasm of larger myelinated nerve fibres traversing the granular layer of the rat cerebellum. Such arrays were more common in an older normal rat than in younger animals but were especially frequent in rats suffering from scrapie. To the walls of the individual tubules ribosome-like particles were attached.

Zusammenfassung

Anhäufungen von longitudinal angeordneten, tubulären Strukturen wurden im Axoplasma dicker bemarkter Nervenfasern, welche die Körnerschicht des Rattenkleinhirns kreuzen, gefunden. Solche Anhäufungen traten häufiger bei alten gesunden Ratten als bei jüngeren Tieren auf, waren aber besonders häufig bei Scrapie-Ratten. Den Wänden der einzelnen Tubuli waren Ribosomen-artige Partikel angelagert.

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Authors and Affiliations

  1. Medical Research Council, Demyelinating Diseases Research Unit, Royal Victoria Infirmary and University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, UK

    C. S. Raine & E. J. Field

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  1. C. S. Raine
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  2. E. J. Field
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Raine, C.S., Field, E.J. Orientated tubules in axoplasm of cerebellar myelinated nerve fibres in the rat. Acta Neuropathol 9, 298–304 (1967). https://doi.org/10.1007/BF00687939

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  • DOI: https://doi.org/10.1007/BF00687939

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