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Polysaccharide accumulation in the central nervous system ofd-penicillamine-treated rats

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Summary

A complex polysaccharide accumulation was observed in the central nervous system (CNS) of rats treated withd-penicillamine similar to Lafora-like bodies. They have histochemical similarities comparable to bodies described in previous studies of Lafora disease. The clinical usefulness ofd-penicillamine has been limited by many side effects including renal damage. It is suggested that, in addition tod-penicillamine nephropathy, there are toxic effects of this drug on the CNS.

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Authors and Affiliations

  1. Department of Surgery, The Rayne Institute, University College Hospital Medical School, WC1E 6JJ, London, UK

    A. Paul Jayaraj

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  1. A. Paul Jayaraj
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Jayaraj, A.P. Polysaccharide accumulation in the central nervous system ofd-penicillamine-treated rats. Acta Neuropathol 51, 237–239 (1980). https://doi.org/10.1007/BF00687391

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  • DOI: https://doi.org/10.1007/BF00687391

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