Summary
Rimmed vacuoles (Dubowitz and Brooke 1973) have been found in 12 cases with various neuromuscular diseases and are considered to be autophagic in nature. They consisted of multilaminated membranous structures accompanied by glycogen granules, dense bodies, and amorphous, granular, and fibrillar material. The contents of the vacuoles were regarded as having partially dissolved out of the vacuoles in cryostat sections but some were plastered along the walls of the vacuoles and were depicted by the staining procedures for light microscopy. The “lined vacuoles” described by Carpenter et al. (1978) in inclusion body myositis closely agree with the rimmed vacuoles in respect of histochemical and ultrastructural features.
Similar content being viewed by others
References
Anderson PJ, Song SK, Slotwinner P (1967) The fine structure of spheromembranous degeneration of skeletal muscle induced by vincristine. J Neuropathol Exp Neurol 26:15–24
Barka T, Anderson PJ (1963) Histochemistry: Theory, practice, and bibliography. Hoeber, New York
Benke B (1976) Mass occurrence of multilamellar bodies in myopathy. Virchows Archiv [Cell Pathol] 20:77–84
Bird JWC (1975) Skeletal muscle lysosomes. In: Dingle JT, Dean RT (eds) Lysosomes in biology and pathology, vol 4. North Holland, Amsterdam Oxford, pp 75–109
Bosch EP, Gowans JDC, Munsat T (1979) Inflammatory myopathy in oculopharyngeal dystrophy. Muscle Nerve 2:73–77
Brooke MH, Engel WK (1969) The histographic analysis of human muscle biopsies with regard to fiber types. 2. Diseases of the upper and lower motor neuron. Neurology (Minneap) 19:378–393
Carpenter S, Karpati G, Heller I, Eisen A (1978) Inclusion body myositis: A distinct variety of idiopathic inflammatory myopathy. Neurology (Minneap) 28:8–17
Clarke JT, Karpati G, Carpenter S, Wolfe LS (1972) The effect of vincristine on skeletal muscle in the rat: A comparative histochemical, ultrastructural, and chemical study. J Neuropathol Exp Neurol 31:247–266
Dubowitz V, Brooke MH (1973) Muscle biopsy: A modern approach. Saunders, London Philadelphia Toronto
Engel AG, Dale AJD (1968) Autophagic glycogenesis of late onset with mitochondrial abnormalities. Light and electron microscopic observations. Mayo Clin Proc 43:233–279
Engel WK, Bishop DW, Cunningham GG (1970) Tubular aggregates in type II muscle fibers: ultrastructural and histochemical correlation. J Ultrastruct Res 31:507–525
Furukawa T, Takagi A, Nakao K, Sugita H, Tsukagoshi H, Tsubaki T (1968) Hereditary muscular atrophy with ataxia, retinitis pigmentosa, and diabetes mellitus. Neurology (Minneap) 18:942–947
Ketelsen U-P (1977) Ultrastructure of dystrophic skeletal muscle. Isr J Med Sci 13:23–36
MacDonald RD, Engel AG (1970) Experimental chloroquine myopathy. J Neuropathol Exp Neurol 29:479–499
Markesbery WR, Griggs RC, Herr B (1977) Distal myopathy: Electron microscopic and histochemical studies. Neurology (Minneap) 27:727–735
Miller RG, Blank NK, Layzer RB (1978) Sporadic distal myopathy with early adult onset. Ann Neurol 5:220–227
Odor DL, Patel AN, Pearce LA (1967) Familial hypokalemic periodic paralysis with permanent myopathy. A clinical and ultrastructural study. J Neuropathol Exp Neurol 26:98–114
Uchino M, Yamamura Y, Kawasaki S, Uekawa K, Tokuomi H (1979) A case report of oculo-pharyngo-distal type myopathy, with vacuolar degeneration and myelin figure in muscle fibres. Clin Neurol (Tokyo) 19:604–608
Yunis EJ, Samaha FJ (1971) Inclusion body myositis. Lab Invest 25:240–248
Author information
Authors and Affiliations
Additional information
This work was supported by a grant from the Ministry of Health and Welfare, Japan
Rights and permissions
About this article
Cite this article
Fukuhara, N., Kumamoto, T. & Tsubaki, T. Rimmed vacuoles. Acta Neuropathol 51, 229–235 (1980). https://doi.org/10.1007/BF00687390
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00687390