Summary
The effect of an extract of Ginkgo biloba was studied on cerebral edema in rats intoxicated with triethyltin chloride (TET). Brains of TET-treated rats showed elevated water and sodium levels and a significant increase in the sodium/potassium ratio. Animals treated with TET plus the extract did not show water and electrolyte changes. The course of intoxication and treatment was studied light-and electron-microscopically. A severe edema with extensive vacuolization was seen in the cerebral and cerebellar white matter. Morphometric measurements revealed a significant decrease in these manifestations of the cytotoxic edema when the animals were treated with an extract of Ginkgo biloba. Thus, we conclude that this extract has a protective effect on the development of a cytotoxic edema in the white matter of the brain.
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Otani, M., Chatterjee, S.S., Gabard, B. et al. Effect of an extract of Ginkgo biloba on triethyltin-induced cerebral edema. Acta Neuropathol 69, 54–65 (1986). https://doi.org/10.1007/BF00687039
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DOI: https://doi.org/10.1007/BF00687039