Summary
Three cases of “neoplastic angioendotheliosis” were examined immunohistochemically by the peroxidase-antiperoxidase method for Factor VIII-related antigen and various leukocyte markers. In all three cases, the tumor cells stained positively for common leukocyte antigen. IgM, and kappa or lambda light chains were demonstrable in two cases. Stains for carcino-embryonic antigen and muramidase were negative. This indicates that the neoplastic cells in the lumen of blood vessels were of lymphoid origin.
This is a preview of subscription content, log in via an institution to check access.
References
Ansell J, Bhawan J, Cohen S, Sullivan J, Sherman D (1982) Histiocytic lymphoma and malignant angioendotheliomatosis. One disease or two? Cancer 50:1506–1512
Beal MF, Fisher CM (1982) Neoplastic angioendotheliosis. J Neurol Sci 53:359–375
Carrol TJ, Goeken JA, Kemp JD (1986) Neoplastic angioendotheliomatosis: further evidence for intravascular malignant lymphomatosis. Lab Invest 54:10A
Crosby TW, Chou SM, Gutrecht J (1976) Neoplastic angioendotheliosis. J Neuropathol Exp Neurol 35:361
Dolman CL, Magil A, Sweeney VP (1979) Neoplastic angioendotheliosis. The case of the missed primary? Arch Neurol 39:5–9
Dolman CL (1984) Ultrastructure of brain tumors and biopsies. A diagnostic atlas, 1st edn. Praeger, New York Philadelphia Eastbourne Toronto Hongkong Tokyo Sydney, pp 107–108
Franssila KO (1985) Thyroid gland. In: Kissane JM () Anderson's pathology, 8th edn, vol 2. CV Mosby, St Louis Toronto Princeton, p 1416
Fulling KH, Gersell DJ (1983) Neoplastic angioendotheliomatosis: histologic, immunohistochemical, and ultrastructural findings in two cases. Cancer 51:1107–1118
Kitagawa M, Matsubara O, Song SY, Kurashima C, Okeda R, Kasuga T (1985) Neoplastic angioendotheliosis. Immunohistochemical and electron microscopic findings in three cases. Cancer 56:1134–1143
Krieger C, Robitaille Y, Jothy S, Elleker G (1982) Intravascular malignant histiocytosis mimicking central nervous system vasculitis. An immunopathological diagnostic approach. Ann Neurol 12:489–492
Mori S, Itoyama S, Mohri N, Shibuya A, Hirose T, Takanashi R, Oshimi K, Mizoguchi H, Epstien AE (1985) Cellular characteristics of neoplastic angioendotheliosis. An immunohistological marker study of six cases. Virchows Arch [A] 407:167–175
Ojeda VJ, Scopa J, Cala LA, Kakulas BA (1984) Multifocal progressive neurological disorder caused by neoplastic angioendotheliosis. Med J Aust 141:246–249
Sheibani K, Battifora H, Winberg CD, Burke JS, Ben-Ezra J, Ellinger GM, Quigley NJ, Fernandez BB, Morrow D, Rappaport H (1986) Further evidence that “malignant angioendotheliomatosis” is an angiotropic large-cell lymphoma. N Engl J Med 314:943–947
Sparling TG, Rosen DA, Corbett WEN, Galbraith PR (1979) Microvascular closure in malignant histocytosis. Can Med Assoc J 120:47–54
Summers BA, deLahunta A (1985) Cerebral angioendotheliomatosis in a dog. Acta Neuropathol (Berl) 68:10–14
Sunohara N, Mukoyama M, Satayoshi E (1984) Neoplastic angioendotheliosis of the central nervous system. J Neurol 231:14–19
Tanaka M, Yamaguchi H, Uchiyama T, Hirai S, Ishezeki J (1982) An autopsy case of malignant lymphoma mimiking neoplastic angioendotheliosis. Rinsho Shinkeigaku 22:507–513
Wick M, Banks PM, McDonald TJ (1981) Angioendotheliomatosis of the nose with fatal systemic dissemination. Cancer 48:2510–2517
Wick M, Scheithauer BW, Ozaki H (1982) Cerebral angioendotheliomatosis. Arch Pathol Lab Med 106:342–346
Yamamura Y, Akamizu H, Hirata T, Kito S, Hamada T (1983) Malignant lymphoma presenting with neoplastic angioendotheliosis of the central nervous system. Clin Neuropathol 2:62–68
Author information
Authors and Affiliations
Additional information
Supported by a B. C. Medical Services Grant, Vancouver Foundation
Rights and permissions
About this article
Cite this article
Dolman, C.L. Immunohistochemistry of socalled “neoplastic angioendotheliosis”. Acta Neuropathol 72, 197–199 (1986). https://doi.org/10.1007/BF00685983
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00685983