Summary
Sulphated acid mucopolysaccharide, probably mainly chondroitin sulphate, has been demonstrated in the cell walls of the tumours of myelin sheath cells.
Its function in relation to insulation and impulse conduction is discussed.
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References
Arima, T., Muramatsu, T., Saigo, K., Egami, F.: Sialomucopolysaccharides from bovine brain. Jap. J. exp. Med.39, 301–309 (1969).
Arseni, C., Carp, N., Mestes, E., Adel, M.: Histochemistry of mucopolysaccharides in brain tumours. Acta neuropath. (Berl.)7, 275–284 (1967).
Ashhurst, D. E., Costin, N. M.: Insect mucosubstances. II. The mucosubstances of the central nervous system. Histochem. J.3, 297–310 (1971).
Barrett, A. J.: The biochemistry and function of mucosubstances. Histochem. J.3, 213–222 (1971).
Benedetti, E. L., Emmelot, P.: Studies on plasma membranes. IV. The ultrastructural localization and content of sialic acid in plasma membrane isolated from rat liver and hepatoma. J. Cell Sci.2, 499–512 (1967).
Bennett, H. S.: Morphological aspects of extracellular polysaccharides. J. Histochem. Cytochem.11, 14–23 (1963).
Bondareff, W.: An intercellular substance in rat cerebral cortex-submicroscopic distribution of Ruthenium red. Anat. Rec.157, 527–536 (1967).
Clausen, J., Rosenkast, P.: Isolation of acid mucopolysaccharides of human brain. J. Neurochem.9, 393–398 (1962).
Dorling, J.: “Critical electrolyte concentration” method in histochemistry. J. med. Lab. Technol.26, 124–130 (1969).
Earle, K. M.: Histochemistry of brain tumours. A study of PAS-positive substances in 486 intracranial neoplasms and 30 intraspinal neoplasms. Lab. Invest.8, 665–672 (1959).
Emmelot, P., Bos, C. J.: On the participation of neuraminidase sensitive sialic acid in the K+ dependent phosphohydrolysis of p-nitrophenyl phosphate by isolated rat liver plasma membranes. Biochim. biophys. Acta (Amst.)115, 244–247 (1966).
Kraemer, P. M.: Sialic acid of mammalian cell lines. J. Cell Physiol.67, 23–24 (1966).
Langley, O. K.: A comparison of the binding of Alcian blue and inorganic cations to polyanions in peripheral nerve. Histochem. J.3, 251–259 (1971).
Margolis, R. U.: Acid mucopolysaccharides and proteins of bovine whole brain, white matter and myelin. Biochim. biophys. Acta (Amst.)141, 91–102 (1967).
Mowry, R. W.: Revised method producing improved coloration of acidic polysaccharides with Alcian Blue 8GX supplied currently. J. Histochem. Cytochem.8, 323 (1960).
Pease, D. C.: Polysaccharides associated with the exterior surface of epithelial cells: kidney, intestine, brain. J. Ultrastruct. Res.15, 555–588 (1966).
Quintarelli, G., Scott, J. E., Dellovo, M. C.: The chemical and histochemical properties of alcian blue. II. Dye binding of tissue polyanions. Histochemie4, 86–98 (1964).
Spicer, S. S.: A correlative study of the histochemical properties of rodent acid mucopolysaccharides. J. Histochem. Cytochem.8, 18–35 (1960).
Spicer, S. S.: Diamine methods for differentiating mucosubstances histochemically. J. Histochem. Cytochem.13, 211–233 (1965).
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Smith, B., Butler, M. Acid mucopolysaccharides in tumours of the myelin sheath cells, the oligodendroglioma and the neurilemmoma. Acta Neuropathol 23, 181–185 (1973). https://doi.org/10.1007/BF00685771
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DOI: https://doi.org/10.1007/BF00685771