Summary
Fourteen juvenile patients with small cell gliomas were studied at two institutes. These tumors are believed to form a distinct entity. They arise mostly in the diencephalon or the brain stem and are composed of a poorly differentiated small cell component having a prononounced tendency to differentiate into a glioma. Signs of neuroblastic differentiation were also found with the electron microscope. Small cell gliomas disseminate early and profusely throughout the ventricular walls and the subarachnoid spaces including the spinal meninges. Prognosis is grave, most patients dying within 1 year of diagnosis or surgical intervention. The designation “infantile small cell glioma” overlaps with both the “metastasising gliomas in young subjects” of Eade and Urich (1971) and with the primitive neuroectodermal tumor of infancy of Hart and Earle (1973).
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References
Ahdevaara P, Kalimo H, Törmö T, Haltia M (1977) Differentiating intracerebral neuroblastoma. Cancer 40:784–788
Boesel CP, Suhan JP, Bradel EJ (1978) Ultrastructure of primitive neuroectodermal neoplasms of the central nervous system. Cancer 42:194–201
Duffner PK, Cohen ME, Heffner RR, Freemann AI (1981) Primitive neuroectodermal tumors of childhood. J Neurosurg 55:376–381
Eade OE, Urich H (1971) Metastasising gliomas in young subjects. J Pathol 103:245–256
Hart MN, Earle KM (1973) Primitive neuroectodermal tumors of the brain in children. Cancer 32:890–897
Horten BC, Rubinstein LJ (1976) Primary cerebral neuroblastoma. Brain 99:735–756
Kosnik EJ, Boesel CP, Bay J, Sayers MP (1978) Primitive neuroectodermal tumors of the central nervous system in children. J Neurosurg 48:741–746
Mannoji H, Takeshita I, Fukui M, Ohta M, Kitamura K (1981) Glial fibrillary acidic protein in medulloblastoma. Acta Neuropathol (Berl) 55:63–69
Markesbery WR, Challa VR (1979) Electron-microscopic findings in primitive neuroectodermal tumors of the cerebrum. Cancer 44:141–147
Parker Jr JC, Mortara RH, McCloskey JJ (1975) Biological behaviour of the primitive neuroectodermal tumors: Significant supratentorial childhood gliomas. Surg Neurol 4:383–388
Rubinstein LJ, Herman MM, Hanbery JW (1974) The relationship between differentiating medulloblastoma and dedifferentiating diffuse cerebellar astrocytoma. Cancer 33:675–690
Schmechel DE, Rakic P (1979) A Golgi study of radial glial cells in developing monkey telencephalon: Morphogenesis and transformation into astrocytes. Anat Embryol 156:115–152
Zülch KJ (1956) Biologie und Pathologie, der Hirngeschwüste. In: Olivecrona H, Tönnis W (Hrsg) Handbuch der Neurochirurgie, Bd 3. Pathologische Anatomie der raumbeengenden intrakraniellen Prozesse. Springer, Berlin Göttingen Heidelberg
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Friede, R.L., Janzer, R.C. & Roessmann, U. Infantile small cell gliomas. Acta Neuropathol 57, 103–110 (1982). https://doi.org/10.1007/BF00685377
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DOI: https://doi.org/10.1007/BF00685377