Summary
Corpus callosum of Jimpy mouse brain was investigated with the electron microscope in 14, 21, 29 days old animals, and compared with that of normal littermates. Myelination was almost lacking in Jimpy; this absence seems to be due to an agenesis rather than a destruction.
The oligodendrocyte cell line is severely disturbed; adult oligodendrocytes are absent in all the animals studied, even in 29 days animals. The few oligodendrocytes present are young; they are found in the vicinity of the few myelinated fibers. Features suggestive of oligodendrocyte death were found both in corpus callosum and neighbouring cortex.
The astrocyte cell line develops normally; evidences of cell reactivity such as increase of glycogen and gliofilaments were found.
Microglia were present in large numbers and contained several types of inclusions, whose signification is discussed.
It is concluded that the defect of myelination in Jimpy mice is closely related to abnormalities found in the oligodendrocyte line.
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Privat, A., Robain, O. & Mandel, P. Aspects ultrastructuraux du corps calleux chez la souris Jimpy. Acta Neuropathol 21, 282–295 (1972). https://doi.org/10.1007/BF00685136
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DOI: https://doi.org/10.1007/BF00685136