Summary
A method is described for the assay of nanogram quantities of diphenhydramine and orphenadrine in human plasma. The procedure employs gas-liquid chromatography and a high sensitivity nitrogen detector. It has been used to assay diphenhydramine in plasma after oral administration of therapeutic doses.
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References
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Bilzer, W., Gundert-Remy, U. Determination of nanogram quantities of diphenhydramine and orphenadrine in human plasma using gas-liquid chromatography. Eur J Clin Pharmacol 6, 268–270 (1973). https://doi.org/10.1007/BF00644744
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DOI: https://doi.org/10.1007/BF00644744