Summary
Using a recently developed computer program based on a correlation between methods to predict the elimination half-life and apparent volume of distribution of cimetidine and actual data from patients, ideal dosage regimens were generated for patients with renal impairment and for geriatric patients, together with the corresponding maximum and minimum steady state concentrations. Using the ideal dosage regimens, practical regimens with feasible dosing intervals of 6, 8 and 12 h were computed, which should result in therapeutic concentrations of 0.4 to 1.3 µg/ml. For uraemic patients and geriatric patients above the age of 75 years it would be desirable to have an additional oral 100 mg dosage form.
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Larsson R, Bodemar G, Norlander B (1979) Oral absorption of cimetidine and its clearance in patient's with renal failure. Eur J Clin Pharmacol 15: 153–157
Somogyi A, Rohner HG, Gugler R (1980) Pharmacokinetics and bioavailability of cimetidine in gastric and duodenal ulcer patients. Clin Pharmacokinet 5: 84–94
Redolfi A, Borgogelli E, Lodola E (1979) Blood level of cimetidine in relation to age. Eur J Clin Pharmacol 15: 257–261
Drayer DE, Romankiewicz J, Lorenzo B, Reidenberg MM (1981) Age of renal clearance of cimetidine. J Clin Pharmacol 31: 45–50
Ritschel WA (1982) Prediction of cimetidine disposition in the aged. APHA meeting, San Diego, California, USA, November 16
Bricker NS, Morris PAF, Kine SW (1960) The pathologic physiology of chronic Bright's disease. Am J Med 28: 77–98
Dost FH (1968) Grundlagen der Pharmakokinetik. Thieme, Stuttgart, p 169
Ritschel WA (1976) Pharmacokinetic approach to drug dosing in the aged. J Am Geriatr Soc 24: 344–354
Delaney JC, Revey M (1977) Cimetidine and mental confusion. Lancet 2: 512
Grimson TA (1977) Reactions to cimetidine. Lancet 1: 855
McMillan MA, Ambis D, Siegel JH (1978) Cimetidine and mental confusion. N Engl J Med 298: 284–285
Wood CA, Isaacson ML, Hibbs MS (1978) Cimetidine and mental confusion. J Am Med Assoc 239: 2550
Schentag JJ, Cerra FB, Callieri G, DeGlopper F, Rose JQ, Bernhard H (1979) Pharmacokinetic and clinical studies in patients with cimetidine-associated mental confusion. Lancet 1: 177–181
Grave W, Nadorp JHSM, Rutten JJMH (1977) Cimetidine and renal failure. Lancet 2: 719–720
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Ritschel, W.A. Cimetidine dosage regimen for patients with renal failure and for geriatric patients. Eur J Clin Pharmacol 23, 501–504 (1982). https://doi.org/10.1007/BF00637496
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DOI: https://doi.org/10.1007/BF00637496