Abstract
Mice treated with low doses of apomorphine tend to adopt a vertical position along the walls of their cage. Optimal conditions have been defined to obtain a reliable dose-response relationship.
This peculiar behavior appears to be elicited by stimulation of dopamine receptors in the striatum: it is suppressed after coagulation of this structure while it is facilitated when these receptors are made hypersensitive by previous treatments with 6-hydroxydopamine or haloperidol; on the other hand, it is not modified by coagulation of the nucleus accumbens.
The relative efficacy of various agonists and antagonists of dopamine receptors have been determined on this test.
It appears that this stereotyped behavior might represent a convenient mean to assess the stimulation of striatal dopamine receptors in mice.
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References
Andén, N. E., Rubenson, A., Fuxe, K., Hokfelt, T.: Evidence for dopamine receptor stimulation by apomorphine. J. Pharm. Pharmacol.19, 627–629 (1967)
Costentin, J., Protais, P., Schwartz, J. C.: Rapid and dissociated changes in sensitivities of different dopamine receptors in mouse brain. Nature (Lond.)257, 405–407 (1975)
Ernst, A.: Mode of action of apomorphine and dexamphetamine on gnawing compulsion in rats. Psychopharmacologia (Berl.)10, 316–323 (1967)
Gianutsos, G., Drawbaugh, R. B., Hynes, M. D., Lal, H.: Behavioural evidence for dopaminergic supersensitivity after chronic haloperidol. Life Sci.14, 887–898 (1974)
Gouret, C.: L'épreuve des redressements à l'apomorphine chez la Souris: son interet comme test de sélection des psychotropes. J. Pharmacol. (Paris)4, 341–352 (1973)
Haley, T. J., McCormick, W. G.: Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse. Brit. J. Pharmacol.12, 12–15 (1957)
Hester, J. B., Rudzik, A. D., Keasling, H. H., Veldkamp, W.: 4′-fluoro-4-(1,4,5,6-tetrahydroazepino 4,5-b indol-3 (2H)-yl butyrophenones. J. med. Chem.13, 23–26 (1970)
Iversen, S. D., Creese, I.: Behavioural correlates of dopaminergic supersensitivity. In: Advances in Neurology, vol. 9, T. N. Calne, Chase, and A. Barbeau, eds., pp. 81–92. New York: Raven Press 1975
Kelly, P. H., Seviour, P. W., Iversen, S. D.: Amphetamine and apomorphine responses in the rat following 6-hydroxydopamine lesions of the nucleus accumbens septi and corpus striatum. Brain Res94, 507–522 (1975)
Lal, H., O'Brien, J., Pitterman, A., Gianutsos, G., Reddy, C.: Aggression after amphetamines and dihydroxyphenylanine. Fed. Proc.13, 529 (1972)
Lal, H., Colpaert, F. C., Laduron, P.: Narcotic withdrawal-like mouse jumping produced by amphetamine andl-Dopa. Europ. J. Pharmacol.30, 113–116 (1975)
Lehmann, A.: Atlas stéréotaxique du cerveau de la Souris. Editions du C.N.R.S. (1974)
Miller, R. J., Iversen, L. L.: Stimulation of a dopamine sensitive adenylate cyclase in homogenates of rat striatum by a metabolite of piribedil (ET 495). Naunyn-Schmiedeberg's Arch. Pharmacol.282, 213–216 (1974)
Mishra, R. K., Makman, M. H.: Effect of I-(3,4-dihydroxy-benzyl)-4(2-pyrimidinyl piperazine) S 584, a metabolite of Piribedil (ET 495) on dopamine stimulated adenyl cyclase of rat caudate and primate caudate and retina. Pharmacologist16, 287 (1974)
Pijnenburg, A. J., Van Rossum, J. M.: Stimulation of locomotor activity following injection of dopamine into the nucleus accumbens. J. Pharm. Pharmacol.25, 1003–1004 (1973)
Protais, P., Costentin, J.: Methode d'étude des agonistes des récepteurs dopaminergiques striataux par l'analyse du comportement de rotation chez la souris. J. Pharmacol. (Paris)7, 251–255 (1976)
Schoenfeld, R., Uretsky, N.: Altered response to apomorphine in 6-hydroxydopamine treated rats. Europ. J. Pharmacol.19, 115–118 (1972)
Senault, B.: Comportement d'aggressivité intraspécifique induit par l'apomorphine chez le rat. Psychopharmacologia (Berl.)18, 271–287 (1970)
Tarsy, D., Baldessarini, R.: Pharmacologically induced behavioural supersensitivity to apomorphine. Nature New Biol.245, 262–263 (1973)
Thornburg, J. E., Moore, K. E.: A comparison of effects of apomorphine and ET 485 on locomotor activity and circling behaviour in mice. Neuropharmacology13, 189–197 (1974)
Ungerstedt, U.: Postsynaptic supersentivity after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system in the rat brain. Acta physiol. scand.367, Suppl. 82, 69–93 (1971)
Ungerstedt, U., Arbutnott, G.: Quantitative recording of rotational behaviour in rats after 6-hydroxydopamine lesions of the nigrostriatal dopamine system. Brain Res.24, 485–493 (1970)
Von Voigtlander, P. F., Losey, E. G., Triezenberg, H. J.: Increased sensitivity to dopaminergic agents after chronic neuroleptic treatment. J. Pharmacol. exp. Ther.193, 88–94 (1975)
Wallach, M. B.: Drug-induced stereotyped behaviour: similarities and differences. In: Neuropsychopharmacology of Monoamines and their Regulatory Enzymes, E. Usdin, ed., pp. 241–260. New York: Raven Press 1974
Weissman, A.: Cliff jumping in rats after intraveinous treatment with apomorphine. Psychopharmacologia (Berl.)21, 60–65 (1971)
Yarbrough, G. G.: Supersensitivity of caudate neurons after repeated administration of haloperidol. Europ. J. Pharmacol.31, 367–369 (1975)
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Protais, P., Costentin, J. & Schwartz, J.C. Climbing behavior induced by apomorphine in mice: a simple test for the study of dopamine receptors in striatum. Psychopharmacology 50, 1–6 (1976). https://doi.org/10.1007/BF00634146
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DOI: https://doi.org/10.1007/BF00634146