Summary
The effects of xamoterol on exercise capacity have been evaluated in 10 patients with angina pectoris and well-preserved left ventricular function. Compared to placebo a single 200 mg dose of xamoterol produced a slight but insignificant increase in exercise capacity. At maximum work load, ST-T segment depression was reduced (3 mm and 2.19 mm after placebo and xamoterol, respectively;p<0.05). The changes paralleled an insignificant reduction in maximal heart rate and pressure-rate product. At rest, xamoterol increased the heart rate from 80 to 86 beats/min. Thus, at rest, when sympathetic tone is low, xamoterol acts as a beta-receptor agonist but during exercise, when sympathetic tone is high, xamoterol acts as an antagonist and reduces myocardial ischaemia.
Similar content being viewed by others
References
Harry JD, Marlow HF, Wardleworth AG, Young J (1981) The action of ICI 118.587 (a beta-adrenoceptor partial agonist) on the heart rate response to exercise in man. Br J Clin Pharmacol 12: 266–267
Marlow HH, Wardleworth AG, Booth LM (1982) The hemodynamic effects of oral doses of ICI 118.587, a beta-adrenoceptor partial agonist, in healthy volunteers. Br J Clin Pharmacol 13: 269–270
Nuttal A, Snow HM (1982) The cardiovascular pharmacology of ICI 118.587: a beta-adrenoceptor partial agonist. Br J Pharmacol 77: 381–383
Hill M, Armitage P (1979) The two-period cross-over clinical trial. Br J Clin Pharmacol 8: 7–20
Detry JM, De Coster PM, Buy JJ, Rousseau MF, Brasseur LA (1984) Anti-anginal effects of Corwin, a new beta-adrenoceptor partial agonist. Am J Cardiol 53: 439–443
Ariens EJ (1964) Molecular pharmacology. The mode of action of biologically active compounds. Academic Press, New York, pp 148–170
Finegan RE, Marlow AM, Harrison DC (1972) Circulatory effect of practolol. Am J Cardiol 29: 315–322
Kostis JB, Frishman W, Hosler MH, Thorsen NL, Gonasum L, Weinstein J (1982) Treatment of angina pectoris with pindolol: the significance of intrinsic sympathomimetic activity of beta blockers. Am Heart J 104 (no. 2, pt 2): 496–504
Awan NA, Needham KE, Evenson MK, Win A, Mason DT (1981) Hemodynamic actions of prenalterol in severe congestive heart failure due to chronic coronary disease. Am Heart J 101: 158–161
Kirlin PC, Pitt B (1981) Hemodynamic effects of intravenous prenalterol in severe heart failure. Am J Cardiol 47: 670–675
Waagstein F, Reiz S, Ariniego R, Hjalmarson A (1981) Clinical results with prenalterol in patients with heart failure. Am Heart J 102: 548–554
Rousseau MF, Pouleur H, Vincent MF (1983) Effects of a cardio-selective beta partial agonist (‘Corwin’) on left ventricular function and myocardial metabolism in patients with previous myocardial infarction. Am J Cardiol 51: 1267–1274
Molajo AO, Coupe MO, Bennett DH (1984) Effect of ‘Corwin’ (ICI 118,587) on resting and exercise heart rate in digitalised patients with chronic atrial fibrillation. Br Heart J 52: 392–395
Simonsen S (1984) Haemodynamic effects of ICI 118,587 in cardiomyopathy. Br Heart J: 654–657
Bala Subramanian V (1983) Comparison of verapamil with propranolol. In: Calcium antagonists in chronic stable angina pectoris. Excerpta Medica, Amsterdam
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Barrios, L., Geboers, J., Piessens, J.H. et al. Effects of xamoterol a new beta-adrenoceptor partial agonist, in patients with angina pectoris. Eur J Clin Pharmacol 29, 667–671 (1986). https://doi.org/10.1007/BF00615956
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00615956