Summary
Single oral doses of rifampicin (RMP) were given to 31 patients with pleural effusions of various aetiologies. The concentrations of RMP and its active metabolites in pleural fluid and plasma were determined by an agar diffusion method using paper discs as diffusion centres. The plasma concentrations reached a peak within 3 h and then declined monoexponentially; in pleural fluid, RMP concentration rose slowly to reach a plateau that lasted for several hours. There were marked differences between subjects in the observed concentrations of RMP. During the first 12 h the plasma levels exceeded those in pleural fluid, but after 24 h the concentration of RMP in pleural fluid was higher than in plasma. If multiple oral doses of RMP 10 mg/kg b. w. are given every 24 h, as is common in the treatment of tuberculosis, therapeutic concentrations may be expected in pleural fluid for the major part of each day.
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Malmborg, A.-S., Boman, G.: Rifampicin levels in pleural fluid. Adv. Antimicrob. Antineopl. Chemother., 123–125. München: Urban & Schwarzenberg 1972
Sensi, P., Maggi, N., Füresz, S., Maffii, G.: Chemical modifications and biological properties of rifamycins. Antimicrob. Agents Chemother. 1966, 699–714 (1967)
Experimental and clinical evaluation of the tuberculostatics. International Colloquium, Borstel, Germany, May 1968. Antibiot. Chemother.16. Basel: S. Karger 1970
A Symposium on Rimactane, Basle, November 1968. Basel: Ciba Ltd.
Symposium Européen Rifampicine, Pellenberg, Belgium, March 1969. Acta tuberc. pneumol. belg.60, 249–588 (1969)
Rifampin in the treatment of pulmonary tuberculosis, Philadelphia, USA, October 1971. Chest61, 517–598 (1972)
Furesz, S., Scotti, R., Pallanza, R., Mapelli, E.: Rifampicin: A new rifamycin. Arzneimittel-Forsch.17, 534–537 (1967)
Canetti, G., Parrot, R., Porven, G., LeLirzin, M.: Les taux de rifampicine dans le poumon et dans les lésions tuberculeuses de l'homme. Acta tuberc. pneumol. belg.60, 315–322 (1969)
Dettli, L.: The pharmacokinetics of Rimactane in patients with normal liver and kidney function. A Symposium on Rimactane, Basle, November 1968, p. 28–31. Basel: Ciba Ltd.
Beeuwkes, H., Buytendijk, H.J., Maesen, F.P.V.: Der Wert des Rifampicin bei der Behandlung von Patienten mit bronchopulmonären Affektionen. Arzneimittel-Forsch.19, 1283–1285 (1969)
Rabinovici, A., Bocchino, M.: Sulla capacitá di passaggio della rifampicina in alcuni materiali organici. Riv. Pat. Clin. Tuberc.42, 329–334 (1969)
Chisholm, G.D., Waterworth, P.M., Calnan, J.S., Garrod, L.P.: Concentration of antibacterial agents in interstitial tissue fluid. Brit. med. J.1973 I, 569–573
Jalling, B., Malmborg, A.-S., Lindman, A., Boréus, L.O.: Evaluation of a micromethod for determination of antibiotic concentrations in plasma. Europ. J. clin. Pharmacol.4, 150–157 (1972)
Lundberg, C., Malmborg, A.-S.: Concentration of penicillin V and tetracycline in maxillary sinus secretion after repeated doses. Scand. J. infect. Dis.5, 123–133 (1973)
Canetti, G., Djurovic, V., LeLirzin, M., Thibier, R., Lepeuple, A.: Etude comparative de l'évolution des taux sanguins de rifampicine chez l'homme par deux méthodes microbiologiques différentes. Rev. Tuberc. (Paris)34, 93–106 (1970)
Lundberg, C., Malmborg, A.-S.: Concentration of penicillin and tetracycline in maxillary sinus secretion after a single dose. Scand. J. infect. Dis. In press (1973)
Maggi, N., Furesz, S., Pallanza, R., Pelizza, G.: Rifampicin desacetylation in the human organism. Arzneimittel-Forsch.19, 651–654 (1969)
Finkel, J.M., Pittillo, R.F., Mellett, L.B.: Fluorometric and microbiological assays for rifampicin and the determination of serum levels in the dog. Chemotherapy (Basel)16, 380–388 (1971)
Kluge, T.: Absorpsjon fra de serøse huler. Nord. Med.82, 913–920 (1969)
Binda, G., Domenichini, E., Gottardi, A., Orlandi, B., Ortelli, E., Pacini, B., Fowst, G.: Rifampicin, a general review. Arzneimittel-Forsch.21, 1907–1978 (1971)
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A preliminary account of this paper was presented to the VIIth International Congress of Chemotherapy, Prague, 1971 (1)
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Boman, G., Malmborg, A.S. Rifampicin in plasma and pleural fluid after single oral doses. Eur J Clin Pharmacol 7, 51–58 (1974). https://doi.org/10.1007/BF00614390
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DOI: https://doi.org/10.1007/BF00614390