Summary
Plasma phenytoin levels were measured in 60 patients under steady-state conditions for a period of six weeks. During the trial, the preparation of phenytoin was changed from Phenytoin BP (Regent) to Epanutin Infatabs. A significant increase in plasma phenytoin levels following the change of tablet was matched by a decrease in the number of seizures.
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Stewart, M.J., Ballinger, B.R., Devlin, E.J. et al. Bioavailability of phenytoin. A comparison of two preparations. Eur J Clin Pharmacol 9, 209–212 (1975). https://doi.org/10.1007/BF00614019
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DOI: https://doi.org/10.1007/BF00614019