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The Funeral Is on Monday

Fatal Forty DDI: phenytoin, valproic acid, CYP2C9

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A Case Approach to Perioperative Drug-Drug Interactions

Abstract

This case discusses a complex pharmacokinetic interaction between phenytoin and valproic acid involving both metabolism and distribution.

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Author information

Authors and Affiliations

  1. Department of Neurology, Presbyterian Medical Group, Albuquerque, NM, USA

    Elizabeth Macri MD

  2. Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, OR, USA

    Ansgar M. Brambrink MD, PhD

  3. Department of Psychiatry, University of Maryland Medical System, VA Maryland Health Care System, Baltimore, MD, USA

    Neil B. Sandson MD

Authors
  1. Elizabeth Macri MD
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  2. Ansgar M. Brambrink MD, PhD
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  3. Neil B. Sandson MD
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Corresponding author

Correspondence to Elizabeth Macri MD .

Editor information

Editors and Affiliations

  1. Anesthesia Services Department, Philadelphia Veterans Affairs Med Center, Philadelphia, PA, USA

    Catherine Marcucci MD

  2. Department of Anesthesiology, Oregon Health and Science University, Portland, OR, USA

    Michael P. Hutchens MD

  3. Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA

    Erica D. Wittwer MD, PhD , Toby N. Weingarten MD , Juraj Sprung MD, PhD  & Wayne T. Nicholson MD, PharmD, MSc , ,  & 

  4. Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, OR, USA

    Kirk Lalwani MD

  5. Department of Anesthesiology, University of Pittsburgh School of Med Liliane S. Kaufmann Building, Pittsburgh, PA, USA

    David G. Metro MD

  6. Department of Anesthesiology, University of Illinois at Chicago, Chicago, IL, USA

    Randal O. Dull MD, PhD

  7. Department of Anesthesiology, Perioperative Medicine, Oregon Health and Science University, Portland, OR, USA

    Christopher E. Swide MD

  8. Department of Learning Health Sciences, University of Michigan Medical School, Ann Arbor, MI, USA

    F. Jacob Seagull PhD

  9. Department of Anesthesiology and Perioperative Medicine, Portland, OR, USA

    Jeffrey R. Kirsch MD (Professor and Chair) (Professor and Chair)

  10. Department of Psychiatry, University of Maryland Medical System VA Maryland Health Care System, Baltimore, MD, USA

    Neil B. Sandson MD

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Macri, E., Brambrink, A.M., Sandson, N.B. (2015). The Funeral Is on Monday. In: Marcucci, C., et al. A Case Approach to Perioperative Drug-Drug Interactions. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7495-1_170

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  • DOI: https://doi.org/10.1007/978-1-4614-7495-1_170

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-7494-4

  • Online ISBN: 978-1-4614-7495-1

  • eBook Packages: MedicineMedicine (R0)

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