Summary
The results of a placebo-controlled, double-blind cross-over study in 13 patients with angina pectoris demonstrated that daily application of a newly developed, transdermal therapeutic system for the administration of nitroglycerin (NTG-TTS) over a period of 14 days reduced the daily frequency of anginal attacks by 67%, and the daily consumption of nitrates by 63%. Systolic and diastolic blood pressures were significantly lowered by 10 mmHg and 7.5 mmHg, respectively. The exercise-induced increase in blood pressure was not influenced by NTG-TTS, but it occurred at a lower level. Heart rate was not increased by NTG-TTS, either at rest or up-on exercise. Exercise-induced depression of the ST segment diminished by about 50%, and anginal attacks were distinctly less severe and of shorter duration during NTG application. Development of tolerance was not detected; on the contrary, the anti-anginal effect was more pronounced in the second than in the first week of medication. NTG had no effect on haematological parameters or blood chemistry, and methaemoglobin formation was not observed. Cutaneous tolerability of the system was good and its application posed no major problem.
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Müller P, Imhof PR, Burkart F, Chu LC, Gérardin A (1982) Human pharmacological studies of a new transdermal system containing nitroglycerin. Eur J Clin Pharmacol 22: 473–480
Bruce RA (1971) Exercise testing of patients with coronary heart disease. Ann Clin Res 3: 323–332
Goldman MJ (1979) In: Goldman MJ (ed) Principles of clinical electrocardiography. 10th edition. Lange Los Altos, CA, pp 143–144
Winer BJ (1971) Statistical principles in experimental design. McGraw-Hill, New York
Lange RL, Reid MS, Tresch DD, Keelan MH, Bernhard VM, Collidge G (1972) Non-atheromatous ischemic heart disease following withdrawal from industrial nitroglycerin exposure. Circulation 46: 666–678
Georgopoulos AJ, Markis A, Georgiadis H (1982) Long-term transdermal nitroglycerin in angina pectoris; absence of tolerance towards anti-anginal effect. Eur Heart J (Submitted for publication)
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Georgopoulos, A.J., Markis, A. & Georgiadis, H. Therapeutic efficacy of a new transdermal system containing nitroglycerin in patients with angina pectoris. Eur J Clin Pharmacol 22, 481–485 (1982). https://doi.org/10.1007/BF00609618
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DOI: https://doi.org/10.1007/BF00609618