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Nitrates

  • Chapter
Pharmacological Treatment of Chronic Stable Angina Pectoris

Part of the book series: Current Cardiovascular Therapy ((CCT))

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Abstract

Nitrate therapy is the oldest treatment modality for angina pectoris. In addition to sublingual nitroglycerin, which is commonly used to relieve acute episodes of angina pectoris, longer-acting preparations for oral use are also available and used to prevent the occurrence of angina. The antianginal effect of nitrates is related to both their dilator actions on veins and arteries, which reduce myocardial oxygen demand. In addition, these agents can exert a vasodilator effect on the coronary tree thus helping to maintain or increase coronary artery blood flow. In this chapter we review the role of nitrates as anti-anginal agents and discuss their mechanism of action and the problem of tolerance and side effects.

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Authors and Affiliations

  1. Department of Cardiology, Hospital de Jove, Gijón, Spain

    Amelia Carro MD, PhD

  2. Cardiac Catheterization Laboratories, Area del Corazón, Hospital Universitario Central de Asturias, Oviedo, Spain

    Pablo Avanzas MD, PhD, FESC

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  1. Amelia Carro MD, PhD
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  2. Pablo Avanzas MD, PhD, FESC
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Correspondence to Amelia Carro MD, PhD .

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  1. Department of Cardiology, Hospital Universitario Central de Asturias, Oviedo, Spain

    Pablo Avanzas

  2. Cardiovascular and Cell Sciences Research Institute, St George's University of London, London, United Kingdom

    Juan Carlos Kaski

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Carro, A., Avanzas, P. (2015). Nitrates. In: Avanzas, P., Kaski, J. (eds) Pharmacological Treatment of Chronic Stable Angina Pectoris. Current Cardiovascular Therapy. Springer, Cham. https://doi.org/10.1007/978-3-319-17332-0_5

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  • DOI: https://doi.org/10.1007/978-3-319-17332-0_5

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