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Long term treatment of moderate hypertension with the beta1-receptor blocking agent metoprolol

II. Effect of submaximal work and insulin-induced hypoglycaemia on plasma catecholamines and renin activity, blood pressure and pulse rate

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Summary

The effect of submaximal work and insulin-induced hypoglycaemia on plasma catecholamines and renin activity was studied in nine males with moderate hypertension before treatment, after one month on placebo and after three months of metoprolol treatment. The maintenance dose used was 50–150 mg three times daily. The placebo caused no change in blood glucose, blood pressure, pulse rate, plasma catecholamines and renin activity, neither under basal conditions nor following submaximal work or insulin-induced hypoglycaemia. Metoprolol significantly reduced blood pressure, pulse rate and plasma renin activity under basal conditions whereas plasma catecholamines were unchanged. During metoprolol treatment the increase in blood pressure and pulse rate in response to submaximal work was reduced, but the plasma noradrenaline response was enhanced and plasma adrenaline unaltered. The decrease in pulse rate after work was positively correlated with the mean plasma metoprolol concentration. The fall in blood glucose after insulin 0.1 IU/kg body weight i. v. and its return to normal was unaffected by metoprolol. Before metoprolol, hypoglycaemia was followed by a pronounced increase in plasma adrenaline, with a maximum after 45 min. During metoprolol the adrenaline increase was even more pronounced. Hypoglycaemia was also followed by a two-fold increase in plasma noradrenaline, both before and during treatment with metoprolol. Plasma renin activity during submaximal work and insulin-induced hypoglycaemia varied as much before as during treatment with metoprolol.

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Authors and Affiliations

  1. Department of Internal Medicine and Endocrinology, General Hospital, Malmö, Sweden

    B. -G. Hansson, J. -F. Dymling, P. Manhem & B. Hökfelt

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  3. P. Manhem
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  4. B. Hökfelt
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Hansson, B.G., Dymling, J.F., Manhem, P. et al. Long term treatment of moderate hypertension with the beta1-receptor blocking agent metoprolol. Eur J Clin Pharmacol 11, 247–254 (1977). https://doi.org/10.1007/BF00607672

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  • DOI: https://doi.org/10.1007/BF00607672

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