Summary
Lorcainide is a promising antiarrhythmic agent that belongs to the class of local anesthetics. It was tested in 7 patients with malignant ventricular arrhythmias that were resistant to other antiarrhythmic agents. Lorcainide was effective in all cases (complete disappearance of arrhythmias in 6 cases and more than 50% disappearance in the 7th case), and the tolerance was within acceptable limits. The drug was effective at rest, as assessed by 24-h dynamic electrocardiographic monitoring, and during physical exercise. Longer studies with more patients are warranted, since the drug appears to be a promising antiarrhythmic agent.
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Cocco, G., Strozzi, C. Initial clinical experience of lorcainide (Ro 13-1042), a new antiarrhythmic agent. Eur J Clin Pharmacol 14, 105–109 (1978). https://doi.org/10.1007/BF00607440
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DOI: https://doi.org/10.1007/BF00607440