Summary
Eight healthy volunteers received hydrochlorothiazide 75 mg as Dichlotride and Esidrex. Maximal plasma levels were significantly (p<0.05) higher after Dichlotride than Esidrex, 512±189 and 376±70 ng/ml, respectively. However, the bioavailability of the two brands of hydrochlorothiazide did not differ significantly as judged by comparison of the AUC0→9h and AUC0→∞, and the urinary recovery of hydrochlorothiazide during 48 hrs.
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Supported by the Swedish Medical Research Council (Grant No. B 75-04X-227-12 C) and Hässle-Ciba-Geigy AB, Gothenburg, Sweden
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Beermann, B., Groschinsky-Grind, M. & Lindström, B. Bioavailability of two hydrochlorothiazide preparations. Eur J Clin Pharmacol 11, 203–205 (1977). https://doi.org/10.1007/BF00606411
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DOI: https://doi.org/10.1007/BF00606411