Summary
The pressor effect of three doses of angiotensin II (AT) and of single doses of norepinephrine (N) and tyramine (T) was measured in sodium replete and deplete rats before and after ganglionic blockade. In sodium deplete rats, plasma renin concentration (PRC) and hematocrit were significantly higher and plasma sodium was significantly lower than in sodium replete rats. The pressor effect of AT, but not that of N and of T was blunted in sodium deplete rats before and after ganglionic blockade. The relationship between the pressor effect of AT and PRC was significantly negative in the combined material of all groups before ganglionic blockade. The correlation was more pronounced after ganglionic blockade, and it became significant also in the sodium deplete group alone. The pressor effect of AT was not significantly related to plasma sodium concentration and hematocrit, while both exhibited a significant correlation with PRC. Results suggest that the influence of sodium depletion on the pressor action of angiotensin may be mediated by preexisting renin or angiotensin levels and that this relationship is influenced by the autonomous nervous system.
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Samwer, KF., Schreiber, M., Molzahn, M. et al. Pressor effect of angiotensin II in sodium replete and deplete rats. Pflugers Arch. 346, 307–318 (1974). https://doi.org/10.1007/BF00596186
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DOI: https://doi.org/10.1007/BF00596186