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Einfluß von Insulin auf den regionalen Phospholipidstoffwechsel des Kaninchengehirns in vivo

Effect of insulin on phospholipid metabolism in various parts of the rabbit's brain in vivo

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Summary

The effects of insulin in massive doses on total phospholipids and individual phospholipid fractions of cerebrum, cerebral cortex, cerebellum and medulla oblongata was studied on rabbits in Pernocton® anaesthesia. The experiments were performed in order to correlate the time course of the decrease in blood glucose with phospholipid changes and concomitant electrographic patterns of the CNS.

  1. 1.

    Statistically significant decreases in phospholipid content of cerebrum, cerebral cortex and cerebellum did not take place until blood sugar levels were lowered to a critical concentration. This concentration was found to be different in various parts of the brain. In the medulla oblongata no significant decrease of phospholipid content was detected.

  2. 2.

    No effect on regional phospholipids was observed when blood sugar levels were highly increased above normal levels by simultaneous administration of insulin and glucose.

  3. 3.

    The decrease in brain lipid phosphorus during insulin hypoglycemia is explained by a diminished rate of synthesis as well as a breakdown of phospholipids vielding energy supply.

Zusammenfassung

An Kaninchen in Pernocton®-Narkose wurde die Wirkung hoher Insulingaben auf Gesamtphospholipide und verschiedene Phospholipidkomponenten von Großhirn, Großhirnrinde, Kleinhirn und Medulla oblongata in zeitlicher Beziehung zur abnehmenden Blutglucosekonzentration und der elektrischen Hirnfunktion untersucht.

  1. 1.

    Statistisch signifikante Verminderungen im Gehalt der Phospholipide traten in Großhirn, Großhirnrinde und Kleinhirn erst mit Unterschreiten einer bestimmten, regional unterschiedlichen, kritischen Blutglucosekonzentration auf. In der Medulla oblongata war keine signifikante Abnahme der Phospholipidgehalte nachweisbar.

  2. 2.

    Es erfolgte keine Veränderung der Phospholipidgehalte einzelner Hirnanteile, wenn durch gleichzeitige Insulin- und Glucoseverabreichung die Blutglucosekonzentration erheblich erhöht wurde.

  3. 3.

    Die Verminderung endogener Phospholipide des Gehirns während Insulinhypoglykämie wird mit einem der Energiebildung dienenden Abbau sowie einer verzögerten Neubildung erklärt.

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Authors and Affiliations

  1. Institut für Normale und Pathologische Physiologie der Universität Köln, Robert Koch-Str. 39, D-5000, Köln

    D. H. Hinzen, P. Becker & U. Müller

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  1. D. H. Hinzen
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  2. P. Becker
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  3. U. Müller
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Mit Unterstützung der Deutschen Forschungsgemeinschaft.

Auszugsweise vorgetragen auf der 38. Tagung (Herbsttagung) der Deutschen Physiologischen Gesellschaft, Erlangen 1970.

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Hinzen, D.H., Becker, P. & Müller, U. Einfluß von Insulin auf den regionalen Phospholipidstoffwechsel des Kaninchengehirns in vivo. Pflugers Arch. 321, 1–14 (1970). https://doi.org/10.1007/BF00594119

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  • DOI: https://doi.org/10.1007/BF00594119

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