Summary
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1.
Studies are reported of rat intestinal perfusion “in vivo” in which data relating to the transport of sugars, sodium, fluid as well as intracellular concentrations of sugars and electrolytes have been obtained.
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2.
A direct linear relationship with a zero intercept between net sodium and net sugar transport has been observed.
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3.
The average intracellular concentration of sugars is always lower than in the luminal fluid and blood; this fact is consistent with the existence of a sugar pump located at the serosal pole of the absorbing cell.
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4.
Intracellular sodium concentration is lower and intracellular potassium concentration is higher than in “in vitro” experíments.
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5.
Cell sodium concentration and content as well as cell water content are increased by raising the luminal glucose concentration. In the same situation cell potassium concentration decreases while cell potassium content remains unchanged.
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6.
Transport phenomena are more efficient in “in vivo” than in “in vitro” experiments.
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Abbreviations
- 3MG:
-
3-O-methyl-d-glucose
- ECS:
-
extracellular space
- PEG:
-
polyethylenglycol
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This work has been supported by a research grant of the Consiglio Nazionale delle Ricerche (C.N.R.), Rome.
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Esposito, G., Faelli, A. & Capraro, V. Sugar and electrolyte absorption in the rat intestine perfused “in vivo”. Pflugers Arch. 340, 335–348 (1973). https://doi.org/10.1007/BF00592311
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DOI: https://doi.org/10.1007/BF00592311