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Acid base status in unanesthetized, unrestrained guinea pigs

  • Heart, Circulation, Respiration and Blood; Environmental and Exercise Physiology
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Abstract

Acid-base status of arterial blood was measured in chronically cannulated, unanesthetized, unrestrained guinea pigs. Normal values were: pH=7.444±0.032,PaCO2=35.7±4.4; HCO −3 =24.4±2.8; BE=+0.4±2.1 (n=69) andPaO2=91.9±7.3 (n=25) (Values are mean±S.D.).

Induction of light anesthesia with thiopentone caused a respiratory depression (decrease inPaO2) accompanied by respiratory acidosis (increase inPaCO2 and decrease in pH) and a development of slight metabolic acidosis (decrease in base excess and standard bicarbonate). Acid base parameters of guinea pigs are compared to those obtained from rats under identical experimental conditions.

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Authors and Affiliations

  1. Department of Zoology, The Hebrew University of Jerusalem, Jerusalem, Israel

    Amir Bar-Ilan & Jacob Marder

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  1. Amir Bar-Ilan
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  2. Jacob Marder
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Bar-Ilan, A., Marder, J. Acid base status in unanesthetized, unrestrained guinea pigs. Pflugers Arch. 384, 93–97 (1980). https://doi.org/10.1007/BF00589520

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  • DOI: https://doi.org/10.1007/BF00589520

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