Summary
The effects of blockade and stimulation of beta adrenergic receptors on mesenteric, renal and hindlimb circulations have been investigated in unanesthetized resting dogs. Propranolol and isoproterenol have been used for beta blockade and stimulation, respectively. The changes in oxygen consumption in the hindlimb following beta receptor stimulation have also been studied in some experiments performed under anesthesia.
Beta receptor blockade was followed by an increase in vascular resistance which was very slight in the kidney, quite marked in the mesenteric bed and still greater in the hindlimb. This effect was accompanied by moderate bradycardia and moderate arterial hypertension.
Beta receptor stimulation caused, besides tachycardia and hypotension, a drop in vascular resistance in mesenteric and hindlimb circulations. In the latter, the effect was greater, it peaked considerably later and was paralleled by an increase in local oxygen consumption.
The data suggest that beta adrenergic receptors mediate a tonic vasodilator influence on the mesenteric and skeletal muscle circulations, in which these receptors abound. The different magnitude and pattern of the vasodilator effect of iso-proterenol in these circulations seem more consistent with a different local metabolic response than with an uneven density of beta receptors. The tonic vasodilator action is practically nil in the kidney, where beta receptors appear to be sparse or absent.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Ahlquist, R. P., Levy, B.: Adrenergic receptive mechanism of canine ileum. J. Pharmacol. exp. Ther.127, 146–149 (1959).
Andersson, R., Mohme-Lundholm, E.: Studies on the relaxing actions mediated by stimulation of adrenergic α- and β-receptors in taenia coli of the rabbit and guinea pig. Acta physiol. scand.77, 372–384 (1969).
Brick, I., Glover, W. E., Hutchison, K. J., Roddie, I. C.: Effects of propranolol on peripheral vessels in man. Amer. J. Cardiol.18, 329–332 (1966).
Brody, T. M., Diamond, J.: Blockade of the biochemical correlates of contraction and relaxation in uterine and intestinal smooth muscle. Ann. N.Y. Acad. Sci.139, 772–780 (1967).
Burks, T. F., Cooper, T.: Enhancement of peripheral α-receptor stimulation by blockade of “silent” β-receptors. Circulat. Res.21, 703–715 (1967).
Chou, C. C., Camm, G. E., Scott, J. B., Haddy, F. J.: The relationship of metabolism to vasoactivity of isoproterenol and propranolol. Physiologist9, 154 (1966).
Corcoran, A. C., Page, I. H.: Renal hemodynamic effects of adrenaline and “Isuprel”. Proc. Soc. exp. Biol. (N. Y.)66, 148–151 (1947).
Eliasch, H., Rosèn, A., Scott, H. M.: Systemic circulatory response to stress of simulated flight and to physical exercise before and after propranolol blockade. Brit. Heart J.29, 671–683 (1967).
Granata, L., Pasque', A., Pinotti, O.: La dinamica cardiaca negli stati di eccitamento, nel cane: modificazioni dopo blocco dei recettori adrenergici beta. Boll. Soc. it. Biol. sper.43, 362–366 (1967).
Green, H. D., Kepchar, J. H.: Control of peripheral resistance in major systemic vascular beds. Physiol. Rev.39, 617–686 (1959).
Harris, W. S., Schoenfeld, C. D., Brooks, R. H., Weissler, A. M.: Reversal of epinephrine effects in the human by beta-adrenergic blockade. Clin. Res.12, 337 (1964).
Jenkinson, D. H., Morton, I. K. M.: The role of α- and β-adrenergic receptors in some actions of catecholamines on intestinal smooth muscle. J. Physiol. (Lond.)188, 387–402 (1967).
Johnsson, G.: The effects of intra-arterially administered propranolol and H 56/28 on blood flow in the forearm. A comparative study of two β-adrenergic receptor antagonists. Acta pharmacol. (Kbh.)25, suppl.2, 63–74 (1967).
Lundholm, L., Mohme-Lundholm, E., Svedmyr, N.: Introductory remarks. In: Second Symposium on Catecholamines. Pharmacol. Rev.18, 255–272 (1966).
Mahon, W. A.: The peripheral vascular effects of beta-adrenergic blocking agents in man. Angiologica3, 304–317 (1966).
Mellander, S., Johansson, B.: Control of resistance, exchange and capacitance functions in the peripheral circulation. Pharmacol. Rev.20, 117–196 (1968).
Nakano, J., Kusakari, T.: Effect of propranolol on the peripheral vascular bed. Nature (Lond.)209, 923–924 (1966).
——: Effect of beta-adrenergic blockade on the cardiovascular dynamics. Amer. J. Physiol.210, 833–837 (1966).
Nayler, W. G., McInnes, I., Swann, J. B., Carson, V., Lowe, T. E.: Effect of propranolol, a beta adrenergic antagonist, on blood flow in the coronary and other vascular fields. Amer. Heart J.73, 207–216 (1967).
———, Race, P., Lowe, T. E.: Effect of adrenergic beta-receptor blocking drugs on blood flow in the coronary and other vascular fields. Cardiovasc. Res.2, 371–378 (1968).
Novelli, G. P., Pagni, E., Francini, R., Cortesini, C.: Sulla esistenza di recettori adrenergici beta nel circolo renale. Minerva anest.34, 765–777 (1968).
Price, H. L., Cooperman, L. H., Warden, J. C.: Control of the splanchnic circulation in man: role of beta-adrenergic receptors. Circulat. Res.21, 333–340 (1967).
Schoop, W., Schmidtke, I.: The effect of beta-adrenergic blocking substances on muscle blood flow in man. Angiologica3, 141–152 (1966).
Shanks, R. G.: The pharmacology of beta sympathetic blockade. Amer. J. Cardiol.18, 308–316 (1966).
—: The peripheral vascular effects of propranolol and related compounds. Brit. J. Pharmacol.29, 204–217 (1967).
Shen, Y., Quiroz, A. C., Burch, G. E., de Pasquale, N. P.: Hemodynamic responses to β-adrenergic blockade in dogs. Amer. Heart J.73, 669–673 (1967).
Sowton, E., Hamer, J.: Hemodynamic changes after beta adrenergic blockade. Amer. J. Cardiol.18, 317–320 (1966).
Spencer, M. P.: The renal vascular response to vasodepressor sympathomimetics. J. Pharmacol. exp. Ther.116, 237–244 (1956).
Author information
Authors and Affiliations
Additional information
A preliminary report of a part of this work has been published in the Boll. Soc. it. Biol. sper.46, 170–173 (1970)
Supported by a grant from the Consiglio Nazionale delle Ricerche, Roma
Rights and permissions
About this article
Cite this article
Granata, L., Braga, E.C., Cevese, A. et al. Beta adrenergic receptor activity in peripheral vascular beds of the unanesthetized dog. Pflugers Arch. 320, 64–78 (1970). https://doi.org/10.1007/BF00588457
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00588457
Key-Words
- Peripheral Circulations
- Beta Receptor Blockade and Stimulation
- Tonic Vasodilator Action of Beta Receptors