Summary
Nitroglycerine caused an increase indp/dt max, whether the drug was administered intravenously or directly into the coronary arteries, provided that aortic blood pressure and LVEDP were kept constant. The small changes in heart rate in our experiments cannot alone account for the increase indp/dt max. Therefore, we conclude that nitroglycerine has a direct positiv inotropic effect on the heart. The decrease ofdp/dt max from intravenous infusions without stabilization of the arterial blood pressure can be explained by reductions of LVEDP and aortic blood pressure.
Zusammenfassung
Intravenöse Nitroglycerininfusionen mit Stabilisierung des arteriellen Blutdruckes und intracoronare Infusionen gehen bei konstantem Aortendruck und unverändertem enddiastolischen Füllungsdruck des linken Ventrikels mit einer Steigerung der maximalen Druckanstiegsgeschwindigkeit im linken Ventrikel einher. Dies kann nicht allein durch die begleitende Frequenzerhöhung erklärt werden. Dem Nitroglycerin muß eine direkte, positiv inotrope Wirkung auf das Herz zugeschrieben werden. Der Abfall der maximalen Druckanstiegsgeschwindigkeit unter i.v. Infusionen ohne Blutdruckstabilisierung muß durch die Abnahme des enddiastolischen Füllungsdruckes des linken Ventrikels und die Senkung des Aortendruckes erklärt werden.
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Raff, W.K., Drechsel, U., Scholtholt, J. et al. Herzwirkung des Nitroglycerins. Pflugers Arch. 317, 336–343 (1970). https://doi.org/10.1007/BF00586582
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DOI: https://doi.org/10.1007/BF00586582