Abstract
Unitary climbing fibre activity has been systematically recorded in the rabbit cerebellar cortex at the level of the Purkinje cell layer every 100 μm along the longitudinal axis of the folium. In one group of animals, spontaneous activity was identified in 197 out of 204 (96.6%) explored layers, and was uninterruptedly present up to 2,400 μm along the folia. In a second group of animals, stimulating electrodes were placed in the inferior olive and it was found that spontaneous or evoked climbing fibre activity was absent in only 19 out of 422 explored layers: 377 (89.3%) showed a spontaneous and 396 (93.8%) a short latency evoked activity.
If some limitations of the method are considered, it can be concluded that all Purkinje cells receive climbing fibre innervation from cells of the inferior olive. The present experiments support the conclusion that the inferior olive is the unique source of climbing fibres.
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Armstrong, D. M.: Functional significance of connections of the inferior olive. Physiol. Rev.54, 358–416 (1974)
Batini, C., Pumain, R.: Données électrophysiologiques sur l'origine des fibres grimpantes. Arch. Ital. Biol.109, 189–209 (1971)
Batini, C., Corvisier, J., Destombes, J., Gioanni, H., Everett, J.: The climbing fibers of the cerebellar cortex, their origin and pathways in cat. Exp. Brain Res.26, 407–422 (1976)
Brodal, A.: Untersuchungen über die olivo-cerebelläre Lokalisation. Z. ges. Neurol. Psychiatr.169, 1–153 (1940)
Chan-Palay, V., Palay, S. L., Brown, J. T., Van Itallie, C.: Sagittal organization of olivo cerebellar and reticulo cerebellar projections: autoradiographic studies with35S-Methionine. Exp. Brain Res.30, 561–576 (1977)
Courville, J.: Distribution of olivo-cerebellar fibers demonstrated by a radioautographic tracing method. Brain Res.95, 253–263 (1975)
Courville, J., Faraco-Cantin, F.: On the origin of the climbing fibers of the cerebellum. An experimental study in the cat with an autoradiographic tracing method. Neuroscience3, 797–809 (1978)
Desclin, J. C.: Histological evidence supporting the inferior olive as the major source of cerebellar climbing fibers in the cat. Brain Res.77, 365–384 (1974)
Destombes, J.: Nouvelles données sur l'origine pontique de certaines fibres grimpantes. J. Physiol. (Paris)67, 265A-266A (1973)
Eccles, J. C., Llinàs, R., Sasaki, K.: The excitatory synaptic action of climbing fibers on the Purkinje cells of the cerebellum. J. Physiol. (Lond.)182, 268–296 (1966)
Eccles, J. C., Ito, M., Szentàgothai, J.: The cerebellum as a neuronal machine, p. 335. Berlin, Heidelberg, New York: Springer 1967
Groenenwegen, H. J., Voogd, J.: The parasagittal zonation within the olivo-cerebellar projection. I. Climbing fiber distribution in the vermis of the cat cerebellum. J. Comp. Neurol.174, 417–488 (1977)
Murphy, M. G., O'Leary, J. L., Cornblath, D.: Axoplasmic flow in cerebellar mossy and climbing fibres. Arch. Neurol.28, 118–123 (1973)
O'Leary, J. L., Dunsker, S. B., Smith, J. M., Inukai, J., O'Leary, M.: Termination of the olivo-cerebellar system in the cat. Arch. Neurol.22, 193–206 (1970)
Sasaki, K., Kawaguchi, S., Shimono, T., Yoneda, Y.: Responses evoked in the cerebellar cortex by the pontine stimulation. Jap. J. Physiol.19, 95–109 (1969)
Szentàgothai, J., Rajkovits, K.: Über den Ursprung der Kletterfasern des Kleinhirns. Z. Anat. Entwickl.-Gesch.121, 130–141 (1959)
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Giorgio Montarolo, P., Raschi, F. & Strata, P. On the origin of the climbing fibres of the cerebellar cortex. Pflugers Arch. 383, 137–142 (1980). https://doi.org/10.1007/BF00581874
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DOI: https://doi.org/10.1007/BF00581874