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Transient effects of norepinephrine on myocardial oxygen balance

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Summary

In conscious dogs with experimental atrioventricular block and with ventricles paced at constant rate the effects of norepinephrine (NE) and isoproterenol (ISO) on coronary flow, coronary resistance, and myocardial O2-balance were investigated. Myocardial O2-s balance, as estimated from continuous measurement of coronary venous O2-s saturation, was used for the discrimination of coronary dilation induced either directly by vascular β-adrenoreceptor stimulation or indirectly by increased myocardial metabolism.

Following bolus injection of NE (0.3 μg/kg) or ISO (0.1 μg/kg) into the pulmonary artery, coronary venous O2-s saturation increased from a control of 25±2% O2-s saturation (mean±S.D.) transiently to 51±5 and 62±5% O2-s saturation respectively. Afterβ 1-adrenoreceptor blockade these increases were reduced to 33±4 and 41±3% O2-s saturation, respectively. The remaining increase after NE was abolished when atropine was given in addition toβ 1-b blockade. Afterβ 1+2-adrenoreceptor blockade neither NE nor ISO injection had an effect on coronary venous O2 saturation. Afterβ 1-b blockade was superimposed on ganglionic blockade NE injection led to a decrease in coronary venous O2-s saturation indicating a ratent α-a activity of NE.

NE seems to act directly viaβ 1-a adrenoreceptors, since no differences were observed in the time courses of changes in coronary venous O2-s saturation after left atrial injection of NE when compared to adenosine.

It is concluded that circulating NE like ISO is able to improve myocardial oxygen balance by a direct vasodilating effect on canine coronary vessels mediated by vascularβ 1-adrenoreceptors.

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  1. Physiologisches Institut der Universität München, Pettenkoferstrasse 12, D-8000, München 2, Federal Republic of Germany

    Wulf von Restorff & Eberhard Bassenge

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  1. Wulf von Restorff
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  2. Eberhard Bassenge
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von Restorff, W., Bassenge, E. Transient effects of norepinephrine on myocardial oxygen balance. Pflugers Arch. 370, 131–137 (1977). https://doi.org/10.1007/BF00581686

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