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No relation between atrial natriuresis and renal blood flow in conscious dogs

  • Transport Processes, Metabolism and Endocrinology; Kidney, Gastrointestinal Tract, and Exocrine Glands
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Summary

Conscious dogs were used to study whether changes in total renal hemodynamics are responsible for diuresis and natriuresis during an experimental increase in left atrial pressure (LAP). To ensure a controlled dietary sodium intake, the dogs (n=8) were chronically kept on ahigh or alow sodium intake diet (HSI; LSI). After the dogs had completely recovered from surgery (carotid loop, thoracotomy, flank incision), LAP was increased by about 10 cm H2O for 60 min by tightening a purse string around the mitral annulus (51 expts). Mean urine volume (V) increased in both groups to a comparable degree. Mean sodium excretion increased somewhat more in HSI dogs, but remained elevated in LSI dogs after the LAP increase. Renal blood flow (electromagnetic flow transducer) and inulin clearance did not change. Renal vascular resistance (RVR) increased by about 20% (HSI) and 15% (LSI). — When the induced LAP increase was terminated, V decreased. RVR decreased in HSI dogs by about −11% and in LSI dogs by about −6% below control values.—It is concluded that volume regulatory mechanisms induced by an experimental LAP increase operate independently of changes in total renal blood flow.

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References

  1. Arndt, J. O., Reineck, H., Gauer, O. H.: Ausscheidungsfunktion und Haemodynamik der Nieren bei Dehnung des linken Vorhofes am narkotisierten Hund. Pflügers Arch.277, 1–15 (1963)

    Google Scholar 

  2. Baisset, A., Montastruc, P.: Polyurie par distension auriculaire chez le chien; rôle de l'hormone antidiurétique. J. Physiol. (Paris)49, 33–36 (1957)

    Google Scholar 

  3. Brennan, L. A., Malvin, R. L., Jochim, K. E., Roberts, D. E.: Influence of right and left atrial receptors on plasma concentrations of ADH and renin. Am. J. Physiol.221, 273–278 (1971)

    Google Scholar 

  4. Epstein, M.: Cardiovascular and renal effects of head-out water immersion in man. Application of the model in the assessment of volume homeostasis. Circ. Res.39, 619–628 (1976)

    Google Scholar 

  5. Gillespie, D. J., Sandberg, R. L., Koike, T. I.: Dual effect of left atrial receptors on excretion of sodium and water in the dog. Am. J. Physiol.225, 706–710 (1973)

    Google Scholar 

  6. Gilmore, J. P., Zucker, I. H.: The contribution of atrial stretch receptors to salt and water homeostasis in the human. Basic Res. Cardiol.70, 355–363 (1975)

    Google Scholar 

  7. Guyton, A. C.: Physics of blood, blood flow, and pressure: hemodynamics. In: Textbook of medical physiology (A. C. Guyton, ed.), p. 235. Philadelphia-London-Toronto: W. B. Saunders Comp. 1976

    Google Scholar 

  8. Habif, D. V., Papper, E. M., Fitzpatrick, H. F., Lowrance, P., Smythe, C. McC., Bradley, S. E.: The renal and hepatic blood flow, glomerular filtration rate, and urinary output of electrolytes during cyclopropane, ether, and thiopental anesthesia, operation, and the immediate postoperative period. Surgery30, 241–255 (1951)

    Google Scholar 

  9. Henry, J. P., Gauer, O. H., Reeves, J. L.: Evidence of the atrial location of receptors influencing urine flow. Circ. Res.4, 85–90 (1956)

    Google Scholar 

  10. Johnson, J. A., Moore, W. W., Segar, W. E.: Small changes in left atrial pressure and plasma antidiuretic hormone titers in dogs. Am. J. Physiol217, 210–214 (1969)

    Google Scholar 

  11. Kaczmarczyk, G., Reinhardt, H. W., Riedel, J., Eisele, R., Gatzka, M., Kuhl, U.: Left atrial pressure and postprandial diuresis in conscious dogs on a high sodium intake. Pflügers Arch.368, 181–184 (1977)

    Google Scholar 

  12. Kahl, F. R., Flint J. F., Szidon, J. P.: Influence of left atrial distention on renal vasomotor tone. Am. J. Physiol.226, 240–246 (1974)

    Google Scholar 

  13. Kaloyanides, G. J., DiBona, G. F., Raskin, P.: Pressure natriuresis in the isolated kidney. Am. J. Physiol.220, 1660–1666 (1971)

    Google Scholar 

  14. Karim, F., Kidd, C., Malpus, C. M., Penna, P. E.: The effects of stimulation of the left atrial receptors on sympathetic efferent nerve activity. J. Physiol. (Lond.),227, 243–260 (1972)

    Google Scholar 

  15. Kinney, M. J., DiScala, V. A.: Renal clearance studies of effect of left atrial distension in the dog. Am. J. Physiol.222, 1000–1003 (1972)

    Google Scholar 

  16. Koch, K. M., Aynedjian, H. S., Bank, N.: Effect of acute hypertension on sodium reabsorption by the proximal tubule. J. Clin. Invest.47, 1696–1709 (1968)

    Google Scholar 

  17. Krees, S. V., Baukal, A. J., Wolff, F. W.: Semiautomated method for the simultaneous colorimetric determination of inulin andp-aminohippuric acid in blood and urine. Am. J. Clin. Pathol.48, 95–99 (1967)

    Google Scholar 

  18. Ledsome, J. R.: The effects of medullary lesions on the reflex response to distension of the pulmonary vein-left atrial junctions. (Abstract) Intern. Symposium on Cardiac Receptors, Leeds, Great Britain (1976)

  19. Ledsome, J. R., Linden, R. J.: A reflex increase in heart rate from distension of the pulmonary-vein-atrial junctions. J. Physiol. (Lond.)170, 456–473 (1964)

    Google Scholar 

  20. Ledsome, J. R., Mason, J. M.: The effects of vasopressin on the diuretic response to left atrial distension. J. Physiol. (Lond.)221, 427–440 (1972)

    Google Scholar 

  21. Lydtin, H., Hamilton, W. F.: Effect of acute changes in left atrial pressure on urine flow in unanesthetized dogs. Am. J. Physiol.207, 530–536 (1964)

    Google Scholar 

  22. Mason, J. M., Ledsome, J. R.: Effects of obstruction of the mitral orifice or distention of the pulmonary vein-atrial junctions on renal and hindlimb vascular resistance in the dog. Circ. Res.35, 24–32 (1974)

    Google Scholar 

  23. Priano, L. L., Traber, D. L., Wilson, R. D.: Barbiturate anesthesia: an abnormal physiologic situation. J. Pharmacol. Exp. Ther.165, 126–135 (1969)

    Google Scholar 

  24. Reinhardt, H. W., Arnold, B., Eigenheer, F., Eisele, R., Gatzka, M., Kuhl, U., Kaczmarczyk, G.: Water and electrolyte excretion during acute reversible mitral stenosis in relation to cardiac output (CO), heart rate (HR) and mean arterial pressure (Pa) in conscious dogs on a low sodium intake. (Abstract) Pflügers Arch.362, R13 (1976)

    Google Scholar 

  25. Reinhardt, H. W., Kaczmarczyk, G., Eisele, R., Arnold, B., Eigenheer, F., Kuhl, U.: Left atrial pressure and sodium balance in conscious dogs on a low sodium intake. Pflügers Arch.370, 59–66 (1977)

    Google Scholar 

  26. Sachs, L.: Statistische Auswertungsmethoden, pp. 293–300. Berlin-Heidelberg-New York: Springer 1968

    Google Scholar 

  27. Slick, G. L., Aguilera, A. J., Zambraski, E. J., DiBona, G. F., Kaloyanides, G. J.: Renal neuroadrenergic transmission. Am. J. Physiol.229, 60–65 (1975)

    Google Scholar 

  28. Torrente, A. de, Robertson, G. L., McDonald, K. M., Schrier, R. W.: Mechanism of diuretic response to increased left atrial pressure in the anesthetized dog. Kidney Intern.8, 355–361 (1975)

    Google Scholar 

  29. Vander, A. J.: Control of renin release. Physiol. Rev.47, 359–382 (1967)

    Google Scholar 

  30. Vatner, S. F.: Effects of hemorrhage on regional blood flow distribution in dogs and primates. J. Clin. Invest.54, 225–235 (1974)

    Google Scholar 

  31. Zehr, J. E., Hasbargen, J. A., Kurz, K. D.: Reflex suppression of renin secretion during distention of cardiopulmonary receptors in dogs. Circ. Res.38, 232–239 (1976)

    Google Scholar 

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Authors and Affiliations

  1. Arbeitsgruppe Experimentelle Anästhesie, Klinikum Charlottenburg, Freie Universität Berlin, Spandauer Damm 130, D-1000, Berlin 19

    G. Kaczmarczyk, F. Eigenheer, M. Gatzka, U. Kuhl & H. W. Reinhardt

Authors
  1. G. Kaczmarczyk
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  2. F. Eigenheer
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  3. M. Gatzka
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  4. U. Kuhl
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  5. H. W. Reinhardt
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The Arbeitsgruppe Experimentelle Anästhesie is member of the Research Group Autonomic Regulations Freie Universität Berlin

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Kaczmarczyk, G., Eigenheer, F., Gatzka, M. et al. No relation between atrial natriuresis and renal blood flow in conscious dogs. Pflugers Arch. 373, 49–58 (1978). https://doi.org/10.1007/BF00581149

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  • DOI: https://doi.org/10.1007/BF00581149

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