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Influence of Ca2+ on red cell deformability and adaptation to sphering agents

  • Heart, Circulation, Respiration and Blood; Environmental and Exercise Physiology
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Summary

The following results indicate the close connection between Ca2+ and red cell deformability: ATP-depleted red cells have a lowered deformability, but chlorpromazine and papaverine return the deformability to normal despite unchanged low ATP-concentrations of the cells. Both drugs are known to displace membrane-bound calcium.

Without significantly decreasing red cell ATP-content, the calcium-ionophore A23187 reduces the deformability in the presence of 10−4 to 10−3 mol external calcium. The ionophore is ineffective in reducing the red cell deformability when the cells are suspended in a calcium-free medium.

The sphering agent lysolecithin is less effective in reducing red cell deformability, when the external calcium-concentration is kept low. Without lysolecithin external Ca2+ is ineffective in reducing red cell deformability for several h.

These results have been interpreted as showing a calcium-induced reduced mobility of the protein moiety in the red cell membrane.

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Authors and Affiliations

  1. Physiologisches Institut der Universität Marburg, Deutschhausstrasse 2, D-3550, Marburg, Federal Republic of Germany

    Heinz Rogausch

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  1. Heinz Rogausch
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Supported by a grant from the Deutsche Forschungsgemeinschaft (Ro 467/1)

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Rogausch, H. Influence of Ca2+ on red cell deformability and adaptation to sphering agents. Pflugers Arch. 373, 43–47 (1978). https://doi.org/10.1007/BF00581148

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  • DOI: https://doi.org/10.1007/BF00581148

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