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Bacterial pathogens, from adherence to invasion: comparative strategies

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Conclusion

This review has considered various aspects of the molecular cross-talks that occur between bacteria and their host eukaryotic cell targets. We have paid particular attention to the determinism of the types of interaction (i.e., association, adherence, invasion) and tried to get across the idea that the nature of the ligand (bacterium)-receptor (host-cell) complex will decide of the outcome of the interaction. Once intracellular, invasive bacteria have evolved different strategies to survive, multiply and spread. In particular we have developed the model ofS. flexneri infection, which is a pradigm of a bacterium that gains access to the host-cell cytoplasm. This certainly allowsS. flexneri to elect the first invaded cell as its major site of multiplication, thus making the disease a purely local destructive process.

It is likely that the current progress of molecular and cellular pathogenesis of infectious diseases will greatly help to define more fundamental research topics, especially in domains such as transmembrane signaling, cytoskeletal reorganization, etc. In addition, a lot will be learnt on the biology of the cell itself. Finally, the design of new vaccines will certainly bear more and more on information obtained by molecular and cellular dissection of infectious processes.

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  1. Unité de Pathogénie, Microbienne Moléculaire, INSERM U 199, Institut Pasteur, 28 rue du Docteur Roux, 15, Paris Cédex, France

    Philippe J. Sansonetti

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Sansonetti, P.J. Bacterial pathogens, from adherence to invasion: comparative strategies. Med Microbiol Immunol 182, 223–232 (1993). https://doi.org/10.1007/BF00579621

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