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Untersuchungen über die teratogene Wirkung von Hydroxyharnstoff während der frühen und embryonalen Entwicklung der Maus

Studies on the teratogenic effects of hydroxyurea during the early and embryonic development in mice

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Summary

In the studies presented pregnant female mice of the NMRI strain were treated chronically from the 6th to 17th day of pregnancy as well as during certain periods of early and embryonic development with different oral doses of hydroxyurea (HU) which were non-toxic for the maternal animals. In addition to increased incidence of embryo resorption and definite delay in development, characteristic skeletal malformations (cyematopathies and embryopathies) for hydroxyurea could be induced. On the basis of different times of application, it was further possible to establish a certain stage specificity as well as organotropism of the substance.

Zusammenfassung

In den vorliegenden Untersuchungen wurden gravide Mäuseweibchen vom Stamm NMRI sowohl chronisch vom 6.–17. Trächtigkeitstag als auch während bestimmter Abschnitte der frühen und embryonalen Entwicklung oral mit verschiedenen, für das Muttertier untoxischen Dosen von Hydroxyharnstoff (HHS) behandelt. Es konnten neben vermehrter Fruchtresorption und deutlichen Entwicklungsverzögerungen für den Hydroxyharnstoff und verwandte Verbindungen charakteristische Skeletmißbildungen (Kyematopathien und Embryopathien) induziert werden. An Hand der unterschiedlichen Applikationszeitpunkte war es ferner möglich, eine gewisse Stadienspezifität sowie Organotropie des Wirkstoffes festzustellen.

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Authors and Affiliations

  1. Bundesgesundheitsamt, Max von Pettenkofer-Institut, Berlin-Dahlem

    R. Roll & F. Bär

  2. Laboratorium für Ernährungshygiene, Deutschland

    R. Roll & F. Bär

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  1. R. Roll
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  2. F. Bär
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Für die korrekte Durchführung der experimentellen Untersuchungen danken wir Frau B.Bach und Frau B.Jordan sehr herzlich.

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Roll, R., Bär, F. Untersuchungen über die teratogene Wirkung von Hydroxyharnstoff während der frühen und embryonalen Entwicklung der Maus. Arch. Toxikol. 25, 150–168 (1969). https://doi.org/10.1007/BF00577764

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  • DOI: https://doi.org/10.1007/BF00577764

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