Summary
Daily intraperitoneal administration of manganese chloride (15 mg/kg) to rats, maintained on an irondeficient diet, produced marked alterations in the activity of succinic dehydrogenase, monoamine oxidase, and in the morphology of the liver. Manganese accumulation was also significantly increased in such rats than after similar treatment to normally fed rats. Iron deficiency leads to increased absorption of manganese which is responsible for increased susceptiblity to manganese toxicity in these animals.
Zusammenfassung
Die tägliche intraperitoneale Verabreichung von Manganchlorid (15 mg/kg) führt an Ratten, die auf eisenarmer Diät gehalten wurden, zu deutlichen Veränderungen in der Aktivität der Succinatdehydrogenase und der Monaminoxydase sowie zu morphologischen Veränderungen der Leber. Die Anreicherung von Mangan war unter diesen Bedingungen signifikant stärker als bei normal gefütterten Ratten. Der Eisenmangel bewirkt eine gesteigerte Resorption von Mangan, was für die erhöhte Mangantoxizität bei diesen Tieren verantwortlich ist.
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Chandra, S.V., Shukla, G.S. Role of iron deficiency in inducing susceptibility to manganese toxicity. Arch Toxicol 35, 319–323 (1976). https://doi.org/10.1007/BF00570272
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DOI: https://doi.org/10.1007/BF00570272