Summary
Oral administration of a single 500 mg dose of guancydine rapidly (30 mins) produces a marked fall in systolic and diastolic blood pressure, which lasts for at least 6 h, and is accompanied by tachycardia. Hypotension and tachycardia are more marked on standing, but conspicuous postural falls seldom occur. The decrease in blood pressure does not depend on angiotensin antagonism by guancydine, as pressor responses to angiotensin, as well as to noradrenaline, are not diminished by the drug. Marked fluid and electrolyte retention also occurs after guancydine administration, and is probably due to a reduction in glomerular filtration rate and increased tubular reabsorption of sodium. The time course of the various effects of guancydine closely parallels changes in the plasma concentration of the drug. A very precise quantitative relationship exists between the hypotensive effect and the log of plasma guancydine concentrations between 1 and 5 µg/ml.
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Leonetti, G., Bonazzi, O., Grazi, S. et al. Cardiovascular and renal effects of acute administration of a new hypotensive compound, guancydine. Eur J Clin Pharmacol 4, 1–9 (1971). https://doi.org/10.1007/BF00568890
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DOI: https://doi.org/10.1007/BF00568890