Summary
In a double-blind experiment in which 5 healthy young men acted as their own controls, administration of 2 g of neomycin sulphate in a single dose, as compared with lactose, in a test meal containing 300000 i.u. of vitamin A palmitate (retinyl palmitate) reduced the levels of plasmaretinol measured over a four-hour period after the meal. This effect may be due to a disruption by neomycin of the intraluminal micellar phase of fat digestion and absorption.
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References
Jacobson, E.D., Chodos, R.B., Faloon, W.W.: An experimental malabsorption syndrome induced by neomycin. Amer. J. Med.28, 524–533 (1960).
Samuel, P., Steiner, A.: Effect of neomycin on serum cholesterol level of man. Proc. Soc. exp. Biol. (N.Y.)100, 193–195 (1959).
Thompson, G.R., MacMahon, M., Claes, P.: Precipitation by neomycin compounds of fatty acid and cholesterol from mixed micellar solutions. Europ. J. clin. Invest.1, 40–47 (1970).
Thompson, G.R., Barrowman, J., Gutierrez, L., Dowling, R.H.: Action of neomycin on the intraluminal phase of lipid absorption. J. clin. Invest.50, 319–323 (1971).
Paterson, J.C.S., Wiggins, H.S.: An estimation of plasma vitamin A and the vitamin A absorption test. J. clin. Path.7, 56–60 (1954).
Kahan, J.: The vitamin A absorption test. 1. Studies on children and adults without disorders in the alimentary tract. Scand. J. Gastroent.4, 313–324 (1969).
Mehta, S.K., Weser, E., Sleisenger, M.H.: Neomycin inhibition of lipolysis in vitro. Proc. Soc. exp. Biol. (N.Y.)125, 905–907 (1967).
Dobbins, W.O., Herrero, B.A., Mansbach, C.M.: Morphological alterations associated with neomycin induced malabsorption. Amer. J. med. Sci.255, 63–67 (1968).
Keusch, G.T., Troncale, F.J., Plaut, A.G.: Neomycin-induced malabsorption in a tropical population. Gastroenterology58, 197–202 (1970).
Rogers, A.I., Bachorik, P.S.: The effect of neomycin sulphate on pancreatic lipase activity. Proc. Soc. exp. Biol. (N.Y.)127, 1236–1240 (1968).
Ganguly, J., Subbaiah, P. V., Parthasarathy, S.: Absorption of lipids. Proc. Biochem. Soc. Dec. 1971.
David, J.S.K., Ganguly, J.: Further studies on the mechanism of absorption of vitamin A and cholesterol. Indian J. Biochem.4, 14–17 (1967).
Erlansson, C., Borgström, B.: The identity of vitamin A esterase of rat pancreatic juice. Biochim. biophys. Acta (Amst.)167, 629–631 (1968).
Forsgren, L.: Studies on the intestinal absorption of labelled fat-soluble vitamins (A, D, E and K) via the thoracic duct lymph in the absence of bile in man. Acta chir. scand. Suppl,399, 1–29 (1969).
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Barrowman, J.A., D'Mello, A. & Herxheimer, A. A single dose of neomycin impairs absorption of vitamin a (retinol) in man. Eur J Clin Pharmacol 5, 199–201 (1973). https://doi.org/10.1007/BF00564903
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DOI: https://doi.org/10.1007/BF00564903