Abstract
In rat the uptake of colloids by the femur and tibia is dependent on bone plasma flow even if other factors modulate the relationship. We warn Nuclear Medicine scientists against the use of colloid uptake measurement as a marker of the bone macrophagic population, especially in situations associated with modified bone plasma flow.
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References
Fordham EW, Ali A, Turner DA (1982) Atlas of total body radionuclide imaging. Harper and Row, Philadelphia
George EA, Hendershott LR, Klos DJ, Domati RM (1980) Mechanism of hepatic extraction of gelatinized99m-technetium sulfur colloid. Eur J Nucl Med 5:241–245
Gross PM, Heistad DD, Marcus ML (1979) Neurohumoral regulation of blood flow to bones and marrow. Am J Physiol 237:440–448
Neumayr A, Falkner R, Vetter H (1955) Die Bestimmung des Blutflusses durch die Leber mit Kolloidalem radioaktiven Gold. Radioaktive Isotope in Klinik und Forschung 33:230
Schoutens A, Bergmann P, Verhas M (1979) Bone blood flow measured by85Sr microspheres and bone seeker clearances in the rat. Am J Physiol 236:H1-H6
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This work was supported by the F.R.S.M. Belgium (contract Crédit aux Chercheurs 1.5.606.83 F)
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Schuind, F., Schoutens, A., Verhas, M. et al. Uptake of colloids by bone is dependent on bone blood flow. Eur J Nucl Med 9, 461–463 (1984). https://doi.org/10.1007/BF00563169
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DOI: https://doi.org/10.1007/BF00563169