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[99mTc]Tc-Phosphate-buffer system as a potential tracer for bone imaging

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Abstract

In this study, phosphate-buffered saline solution (PBS) was successfully radiolabeled with technetium-99m. The biodistribution profile and bone accumulation of the [99mTc]Tc-PBS system were evaluated in healthy swiss mice. The radiolabeling of the system was successfully obtained, yielding around 90 % of radiochemical purity. The system stability was tested in the presence of saline medium at 25 ºC and mouse plasma at 37 ºC, and results revealed that [99mTc]Tc-PBS showed excellent stability over time, in both media. It was observed a biphasic clearance profile, with fast elimination from the bloodstream by renal filtration. The radiolabeled system revealed a high specificity bone accumulation was observed, demonstrating an uptake behavior from 20 to 50 times higher than muscle, used as control. From all results obtained, the system constituted by [99mTc]Tc-PBS can be considered a potential selective agent for bone imaging.

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Acknowledgements

The authors would like to thank Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG-Brazil), Conselho Nacional de Desenvolvimento Científico e tecnológico (CNPq-Brazil), and Comissão Nacional de Energia Nuclear (CNEN-Brazil) for their financial support and scholarship.

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Author notes

  1. Nara Caroline Pereira and Juliana de Oliveira Silva have contributed equally to this work.

Authors and Affiliations

  1. Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Universidade Federal de Minas Gerais, 31270-901, Belo Horizonte, Minas Gerais, Brazil

    Nara Caroline Pereira, Juliana de Oliveira Silva, Sued Eustáquio Mendes Miranda & André Luis Branco de Barros

  2. Laboratório de Sistemas Poliméricos e Supramoleculares, Instituto de Física e Química, Universidade Federal de Itajubá, 37500-903, Itajubá, Minas Gerais, Brazil

    Frederico B. De Sousa

  3. Laboratório de Bioengenharia, Instituto de Ciências Puras e Aplicadas, Universidade Federal de Itajubá, 35903-087, Itabira, Minas Gerais, Brazil

    Daniel Crístian Ferreira Soares

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  1. Nara Caroline Pereira
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  2. Juliana de Oliveira Silva
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Correspondence to Daniel Crístian Ferreira Soares or André Luis Branco de Barros.

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Pereira, N.C., de Oliveira Silva, J., De Sousa, F.B. et al. [99mTc]Tc-Phosphate-buffer system as a potential tracer for bone imaging. J Radioanal Nucl Chem 329, 1119–1124 (2021). https://doi.org/10.1007/s10967-021-07869-8

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  • DOI: https://doi.org/10.1007/s10967-021-07869-8

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