Summary
Plasma concentrations of methaqualone were followed for several days after single oral doses in 5 healthy subjects. The analysis of methaqualone was performed by gas chromatography-mass spectrometry (mass fragmentography). The plasma levels of methaqualone were interpreted according to a two compartment model. The elimination rate of methaqualone was found to be much slower than has been reported previously, half lives in the β-phase ranging from 19.6 to 41.5 h.
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Alván, G., Lindgren, JE., Bogentoft, C. et al. Plasma kinetics of methaqualone in man after single oral doses. Eur J Clin Pharmacol 6, 187–190 (1973). https://doi.org/10.1007/BF00558284
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DOI: https://doi.org/10.1007/BF00558284