Summary
The effect of intramuscular atropine (0.6 mg) on the absorption of orally administered lidocaine (400 mg) was investigated in four healthy volunteers and in 12 laparoscopy patients. The time taken to achieve peak plasma lidocaine concentration was significantly delayed when lidocaine and atropine were given at the same time. The mean individual peak plasma lidocaine concentrations were reduced by atropine but the differences were not statistically significant. Anaesthesia and laparoscopy caused a further inhibition of lidocaine absorption. Atropine probably delayed the absorption of lidocaine by inhibition of gastric emptying.
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Adjepon-Yamoah, K.K., Scott, D.B. & Prescott, L.F. The effect of atropine on the oral absorption of lidocaine in man. Eur J Clin Pharmacol 7, 397–400 (1974). https://doi.org/10.1007/BF00558214
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DOI: https://doi.org/10.1007/BF00558214