Summary
An association between adenovirus and liver cell damage, although suspected, has not been frequently demonstrated in the human. In this presentation the necropsy of a two month old female infant with thymic dysplasia will be reported who died with liver necrosis in the absence of pulmonary changes. Sections of the liver showed numerous Feulgen-positive intranuclear inclusions with a distinct mosaic-like pattern on high magnification. Adenovirus was isolated from the liver and identified as type 2 by hemagglutination-inhibition and neutralisation tests. Electronmicroscopy of the liver showed considerable multiplication of the virus in most of the liver cells. The characteristic para-crystalline array of the virions could frequently be seen. The appearance of the virion, its size, and cellular distribution was typical of an adenovirus.
This appears to be the first instance in which adenovirus has actually been shown by electron-microscopy in the human liver, and the third instance in which liver necrosis due to adenovirus was associated with thymic dysplasia.
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References
Angella, J. J., Connor, J. D.: Neonatal infection caused by adenovirus type 7. J. Pediat. 72, 474 (1968).
Benyesh-Melnick, U., Rosenberg, H. S.: The isolation of adenovirus type 7 from a fatal case of pneumonia and disseminated disease. J. Pediat. 64, 83 (1964).
Davis, E. V.: Isolation of viruses from children with infectious hepatitis. Science 133, 2059 (1961).
Duic, A., Crozier, D. N., McClure, P. D.: Swiss agammaglobulinemia with hypoglycemia, osseous changes and eosinophilia. Canad. med. Ass. J. 103, 64 (1970).
Dvořáčková, I., Vortel, V., Hroch, M.: Encephalitic syndrome with fatty degeneration of viscera. Arch. Path. 81, 240 (1969).
Embil, J., Faulkner, R. S.: Human diploid cell strains and their susceptibility to viruses. Canad. J. publ. Hlth 55, 111 (1964).
Hartwell, W. V., Love, G. J., Eidenbock, M. P.: Adenovirus in blood clots from cases of infectious hepatitis. Science 152, 1390 (1966).
Haworth, J. C., Hoogstraten, J., Taylor, H.: Thymic alymphoplasia. Arch. Dis. Childh. 42, 40 (1967).
Herrmann, E. C.: Experience in laboratory diagnosis of adenovirus infections in routine medical practice. Mayo Clin. Proc. 43, 635 (1968).
Hillis, W. D.: Cited by W. B. Strong. Adenovirus isolations from patients with infectious hepatitis. CDC Hepatitis Surveillance Report No. 22, p. 17, Atlanta, Georgia (1965).
Köhler, H., Apodaca, J., Lange, W.: Hepatitis bei Affen nach Verimpfung von Adenoviren aus Menschen mit Virushepatitis. — IV. Immunisierungs- und Belastungsversuche. Zbl. Bakt. 209, 423 (1968).
Köhler, H., Apodaca, J., Springer, D.: Über die mehrmalige Isolierung bisher beim Menschen unbekannter Adenoviren aus Patienten mit Virushepatitis mit Hilfe histologischer Verfahren. Zbl. Bakt. 202, 11 (1967).
Kusano, N., Kawai, K., Aoyama, Y.: Intranuclear inclusion body in fatal infantile pneumonia due to adenovirus. Jap. J. exp. Med. 28, 301 (1958).
Mollenhauer, H. M.: Plastic embedding mixtures for use in electron microscopy. Stain Technol. 39, 111 (1964).
Rose, H. M.: The adenoviruses. In: Diagnostic procedures for viral and rickettsial diseases, 4th. ed., edited by E. H. Lennette and N. J. Schmidt, p. 205, New York: American Public Health Association Inc. 1969.
Rosen, L.: A hemagglutination-inhibition technique for typing adenoviruses. Amer. J. Hyg. 71, 120 (1960).
Sell, S.: Immunological deficiency diseases. Arch. Path. 86, 95 (1968).
Sterner, G.: Adenovirus infection in childhood. An epidemiological and clinical survey among Swedish children. Acta. paediat/Uppsala, Suppl. 142 (1962).
Strong, W. B.: Adenovirus isolation from patients with infectious hepatitis. CDC Hepatitis Surveillance Report No. 22, p. 17, Atlanta, Georgia (1965).
Waldman, T.: Disorders of immunoglobulin metabolism. New Engl. J. Med. 281, 1170 (1969).
Wigger, H. J., Blanc, W. A.: Fatal hepatic and bronchial necrosis in adenovirus infection with thymic alymphoplasia. New Engl. J. Med. 275, 870 (1966).
Zuckerman, A. J.: Virus diseases of the liver. London: Butterworth & Co. Ltd. 1970.
Zuckerman, A. J., Bird, R. G., Dunkley, R. J., Love, G. J.: Examination by electron microscope of the San Carlos viruses isolated from children with infectious hepatitis. J. clin. Path. 22, 40 (1969).
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This work was supported by Canadian Federal Public Health Research Grant No. 602-7-97 (to Dr. J. Embil). Presented at the Meeting of the Canadian Association of Pathologists, Sherbrooke, Quebec, 1972.
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Aterman, K., Embil, J., Easterbrook, K.B. et al. Liver necrosis, adenovirus type 2 and thymic dysplasia. Virchows Arch. Abt. A Path. Anat. 360, 155–171 (1973). https://doi.org/10.1007/BF00543226
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DOI: https://doi.org/10.1007/BF00543226