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Zur Ototoxizität von Lokalanästhetika. Eine tierexperimentelle Studie

The ototoxicity of local anesthetics

  • II. Teil: Sitzungsbericht
  • Onkologie Klinische Forschung
  • Published:
Archives of oto-rhino-laryngology Aims and scope Submit manuscript

Summary

In 67 guinea pigs, the compound action potentials and cochlear microphonics were led off over a period of 8 days via an indwelling electrode after the bulla tympanica of the animals had been perfused with 1% local anesthetic solutions (tetracaine, lidocaine with and without epinephrine). At first there was a reversible reduction in the functional capacity of the internal ear. A subsequent short recovery phase was followed by an irreversible constant loss of hearing.

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Literatur

  1. Cutt RA (1963) The effects of the local application of middle ear drugs upon the cochlear potentials. Laryngoscope 73: 702–712

    Article  CAS  Google Scholar 

  2. Höft J (1968) Elektronenmikroskopische Untersuchungen über die Durchlässigkeit der Membran des runden Fensters beim Meerschweinchen. Arch Klin Exp Ohr Nas Kehlk Heilkd 191: 539–540

    Article  Google Scholar 

  3. von Ilberg C (1968) Elektronenmikroskopische Überprüfung der Zugangswege zum Cortischen Organ. Arch Klin Exp Ohr Nas Kehlk Heilkd 191: 540–541

    Article  Google Scholar 

  4. Knothe J, Flach M, Seidel P (1968) Die Wirkung von Kokain und Tetracain auf die elektrische Aktivität der Meerschweinchencochlea. Laryngol Rhinol Otol (Stuttg) 47: 434–441

    CAS  Google Scholar 

  5. Matthias R, Handrock M (1980) Zur Wirkung ototoxischer Substanzen bei intratympanaler Applikation. Arch Otorhinolaryngol 227: 417–420

    Article  CAS  Google Scholar 

  6. Rahm WE, Strother WF, Gulick WL, Crump JF (1959) The effects of topical anesthetics upon the ear. Ann Otol Rhinol Laryngol 68: 1037–1046

    Article  Google Scholar 

  7. Ristow W (1968) Zur Behandlung der Ménière-Krankheit mittels temporärer Labyrinthanästhesie. Laryngol Rhinol Otol (Stuttg) 47: 442–448

    CAS  Google Scholar 

  8. Schätzle W, von Westernhagen B (1969) Über den Einfluß lokaler Pantocain-Applikation auf Fermente der Cochlea und des peripheren Vestibularapparates. Arch Klin Exp Ohr Nas Kehlk Heilkd 194: 583–588

    Article  Google Scholar 

  9. Vanderbeek FB (1952) Anesthesia of internal ear following application of topical anesthetic to middle ear. Arch Otolaryngol 55: 602–603

    Article  CAS  Google Scholar 

  10. Völger G (1952) Beseitigung von Labyrinthliquordruckstörungen bei dem Ménièreschen Symptomenkomplex durch das Hyaluronidasepräparat Kinetin. HNO 3: 142–147

    Google Scholar 

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Authors and Affiliations

  1. Berlin

    R. Matthias, M. Handrock & U. Schüssler

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  1. R. Matthias
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  2. M. Handrock
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  3. U. Schüssler
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Matthias, R., Handrock, M. & Schüssler, U. Zur Ototoxizität von Lokalanästhetika. Eine tierexperimentelle Studie. Arch Otorhinolaryngol 231, 825–828 (1981). https://doi.org/10.1007/BF00501763

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  • DOI: https://doi.org/10.1007/BF00501763

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