Abstract
An ecological approach to the pathogenesis of uncomplicated urinary tract infections allows awareness of the continual battle being waged in the vagina, urethra, and bladder between the bacterial invaders and the host defense mechanisms. Despite overwhelming odds, the bacteria must be able to persist, colonize, and finally adhere to these various battlefields on their ascent to the bladder itself. The large number of patients presenting to physician offices with acute simple cystitis attests to the fact that the bacteria occasionally win the battle of the bladder. An understanding of the pathophysiology of this constantly raging battle may help us modify our clinical approach to women with simple uncomplicated urinary tract infections.
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References
Stamey TA. Urinary infections. Baltimore: Williams and Wilkins, 1980
Sparling PF. Bacterial virulence and pathogenesis: an overview. Rev Infect Dis 1983; (Suppl 4):637–646
Reid G, Sobel JD. Bacterial adherence in the pathogenesis of urinary tract infection: a review. Rev Inf Dis 1987; 9:470–487
Sobel JD, Kaye D. Host factors in the pathogenesis of urinary tract infections. Am J Med 1987; 76:122–130
Parsons CL, Stauffer C, Schmidt JD. Bladder surface glycosaminoglycans: an efficient mechanism of environmental adaptations. Science 1980; 208:605–607
Kunin CM. Detection, prevention and management of urinary tract infections. Philadelphia: Lea and Febiger, 1987
Harrison LH (ed.). Management of urinary tract infections. London: Royal Society of Medicine Services, 1990
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Nickel, J.C. The battle of the bladder: The pathogenesis and treatment of uncomplicated cystitis. Int Urogynecol J 1, 218–222 (1990). https://doi.org/10.1007/BF00499022
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DOI: https://doi.org/10.1007/BF00499022