Summary
159 primary breast carcinomas were examined histologically with regard to grade of anaplasia, cellularity, amount of elastic tissue, and whether they were of ductal or lobular origin. Possible correlations between these variables and the oestrogen receptor (OR)-content were investigated. There was a marked tendency toward a greater number of OR-positive tumors in the group rich in elastosis. A significant correlation between the OR-content and the histological grade was found, whereas there was no correlation between either the OR-content or the grade of anaplasia and the cellularity. Furthermore, the group of tumors that were lobular in derivation had a significantly greater number of OER-positive tumors than the group ductally derived.
Similar content being viewed by others
References
Antoniades K, Spector H (1979) Correlation of estrogen receptor levels with histology and cytomorphology in human mammary cancer. Am J Clin Pathol 71:497–503
Armitage P (1971) Statistical methods in medical research. Blackwell Scientific Publication, Oxford
Aspegren K, Håkansson L (1974) Human mammary carcinoma studied for hormone responsiveness in short term incubations. Acta Clin Scand 140:95–99
Azzopardi JG, Laurini RN (1974) Elastosis in breast cancer. Cancer 33:174–183
Bloom HJG, Richardson WW (1957) Histological grading and prognosis in breast cancer. Br J Cancer 11:359–377
Daehnfeldt JL, Briand P (1977) Determinations of high affinity gestagen receptors in hormone responsive and hormone independent GR mouse mammary tumors by an exchange assay. Progress in cancer research and therapy, Vol 4. Raven Press, New York
Feherty P, Farrer-Brown G, Kellie AE (1971) Oestradiol receptors in carcinoma and benign disease of the breast: an in vitro assay. Br J Cancer 25:697–710
Fisher ER, Redmond CK, Hannen L, Rockette H, Fisher B (1980) Correlation of estrogen receptor and pathologic characteristics of invasive breast cancer. Cancer 45:349–353
Johansson H, Terenius L, Thorén L (1970) The binding of estradiol-17-beta to human breast cancers and other tissues in vitro. Cancer Res 30:692–698
Knight WA, Livingston RB, Gregory EF, McGuire WL (1977) Estrogen receptor as an independent prognositc factor for early recurrence in breast cancer. Cancer Res 37:4669–4671
Lundmark D (1972) Breast cancer and elastosis. Cancer 30 II:1195–1201
Martin PM, Rolland PH, Jacquemin J, Rolland AM, Toga M (1979) Multiple steroid receptors in human breast cancer. Cancer Chemother. Pharmacol 2:115–120
Martin PM, Rolland PH, Jacquemin J, Rolland AM, Toga M (1978) Estradiol receptors (ER) in human breast cancer: necessity of correlation with anatomopathologic examination. ICI Supplement
Masters JRW, Sangster K, Hawkins RA, Shivas AA (1976) Elastosis and oestrogen receptors in human breast cancer. Br J Cancer 33:342–343
Masters JRW, Hawkins RA, Sangster K, Hawkins W, Smith II, Shivas AA, Roberts MM, Forrest APM (1978) Oestrogen receptors, cellularity, elastosis and menstrual status in human breast cancer. Eur J Cancer 14:303–307
Masters JRW, Millis RR, King RJB, Rubens RD (1979) Elastosis and response to endocrine therapy in human breast cancer. Br J Cancer 39:536–540
Maynard PV, Davies CJ, Blamey RW, Elston CW, Johnson J, Griffiths K (1978) Relationship between oestrogen-receptor content and histological grade in human primary breast tumors. Br J Cancer 38:745–748
McGuire WL, Carbone PP, Vollmer EP (1975) Estrogen receptors in human breast cancer. Raven Press, New York
Rosen PP, Menendez-Botet CJ, Nisselbaum JS, Urban JA, Miké V, Fracchia A, Schwarte MK (1975) Pathological review of breast lesions analyzed for estrogen receptor protein. Cancer Res 35:3187–3194
Sander S (1968) The in vitro uptake of oestradiol in biopsies from 25 breast cancer patients. Acta Pathol Microbiol Scand 74:301–303
Schiødt T (1966) Breast carcinoma. A histologic and prognostic study of 650 followed-up cases. Munksgaard, Copenhagen
Shivas AA, Douglas JG (1972) The prognostic significance of elastosis in breast carcinoma. JR Coll Surg Edinb 17:315–320
Terenius L, Johansson H, Rimsten Å, Thorén E (1974) Malignant and benign human mammary disease: estrogen binding in relation to clinical data. Cancer 33:1364–1368
Author information
Authors and Affiliations
Additional information
Sponsored by the Danish Cancer Society
Rights and permissions
About this article
Cite this article
Rasmussen, B.B., Rose, C., Thorpe, S.M. et al. Histopathological characteristics and oestrogen receptor content in primary breast carcinoma. Virchows Arch. A Path. Anat. and Histol. 390, 347–351 (1981). https://doi.org/10.1007/BF00496564
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00496564