Summary
Rat spinal cord, dorsal root ganglia and skin were investigated employing immunohistochemical technique with specific antisera to neurokinin A and substance P. Neurokinin A-like immunoreactivity was detected in the spinal dorsal horn and skin with a similar distribution pattern as that of substance P-like immunoreactivity. After dorsal root transection a parallell decrease of neurokinin A and substance P-like immunoreactivity was observed in the dorsal horn. Using colchicine pretreatment a population of neurokinin A positive cell bodies was seen in the dorsal root ganglia, and by comparison of consecutive sections of the same cells stained for substance P it was revealed that these neurons also display substance P-like immunoreactivity. However, substance P-, but not neurokinin A-, immunoreactive cells were also observed. It is concluded that neurokinin A- and substance P-like immunoreactivity coexist in a population of rat primary sensory neurons.
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Dalsgaard, C.J., Haegerstrand, A., Theodorsson-Norheim, E. et al. Neurokinin A-like immunoreactivity in rat primary sensory neurons; coexistence with substance P. Histochemistry 83, 37–39 (1985). https://doi.org/10.1007/BF00495297
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DOI: https://doi.org/10.1007/BF00495297